NXF2

NXF2
Identifiers
Aliases	NXF2 , CT39, TAPL-2, TCP11X2, nuclear RNA export factor 2
External IDs	OMIM: 300315; MGI: 1933192; HomoloGene: 88604; GeneCards: NXF2; OMA:NXF2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.1 Start 102,247,167 bp [1] End 102,326,722 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X F1|X 56.31 cM Start 133,845,275 bp [2] End 133,865,503 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis right uterine tube pituitary gland anterior pituitary olfactory zone of nasal mucosa hypothalamus islet of Langerhans Top expressed in spermatid Gonadal ridge embryo embryo testicle spermatocyte seminiferous tubule embryo ganglion of neuraxis genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding RNA binding Cellular component cytoplasm nuclear RNA export factor complex nucleus nucleoplasm cytosol Biological process multicellular organism development poly(A)+ mRNA export from nucleus mRNA transport RNA transport mRNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56001 83454 Ensembl ENSG00000269405 ENSMUSG00000009941 UniProt Q9GZY0 n/a RefSeq (mRNA) NM_022053 NM_001039910 NM_017809 NM_001289735 NM_001289736 NM_031259 RefSeq (protein) NP_071336 NP_001093156 n/a Location (UCSC) Chr X: 102.25 – 102.33 Mb Chr X: 133.85 – 133.87 Mb PubMed search [3] [4]
Wikidata
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Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene. ^{[5] [6] [7]}

Function

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene. ^[7]

Interactions

NXF2 has been shown to interact with NUP214. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000269405 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009941 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC   86553 . PMID   11073998.
6. Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID   11279525. S2CID   14200121.
7. "Entrez Gene: NXF2 nuclear RNA export factor 2".

Further reading

• Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC   84993 . PMID   10567585.
• Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology. 11 (18): 1381–1391. Bibcode:2001CBio...11.1381J. doi: 10.1016/S0960-9822(01)00419-5 . PMID   11566096.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.