NXF2

NXF2
Identifiers
Aliases	NXF2 , CT39, TAPL-2, TCP11X2, nuclear RNA export factor 2
External IDs	OMIM: 300315 MGI: 1933192 HomoloGene: 88604 GeneCards: NXF2
Gene location (Human)
Chr.	X chromosome (human)
End	102,326,722 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,865,503 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; hypothalamus; ; islet of Langerhans; ; nucleus accumbens; ; right lung; ; temporal lobe; ; amygdala; ; putamen;
	Top expressed in
	spermatid; ; testicle; ; spermatocyte; ; seminiferous tubule; ; cumulus cell; ; ovary; ; neck; ; carotid body; ; digastric muscle; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding ; RNA binding ;
Cellular component	cytoplasm ; nuclear RNA export factor complex ; nucleus ; nucleoplasm ; cytosol ;
Biological process	multicellular organism development ; poly(A)+ mRNA export from nucleus ; mRNA transport ; RNA transport ; mRNA export from nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	56001
	83454
	ENSG00000269405
	ENSMUSG00000009941
	Q9GZY0
	n/a
	NM_022053 ; NM_001039910 ; NM_017809
	NM_001289735 ; NM_001289736 ; NM_031259
	NP_071336 ; NP_001093156
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 07, 2024

Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.^[5]^[6]^[7]

Function

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.^[7]

Interactions

NXF2 has been shown to interact with NUP214.^[5]

Related Research Articles

Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the NXF1 gene.

Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene.

RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.

Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.

DNA-directed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene.

snRNA-activating protein complex subunit 3 is a protein that in humans is encoded by the SNAPC3 gene.

snRNA-activating protein complex subunit 2 is a protein that in humans is encoded by the SNAPC2 gene.

U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene.

The TREX (TRanscription-EXport) complex is a conserved eukaryotic multi-protein complex that couples mRNA transcription and nuclear export. The TREX complex travels across transcribed genes with RNA polymerase II. TREX binds mRNA and recruits transport proteins NXF1 and NXT1, which shuttle the mRNA out of the nucleus. The TREX complex plays an important role in genome stability and neurodegenerative diseases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000269405 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009941 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553 . PMID 11073998.
↑ Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID 11279525. S2CID 14200121.
1 2 "Entrez Gene: NXF2 nuclear RNA export factor 2".

Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC 84993 . PMID 10567585.
Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology. 11 (18): 1381–1391. Bibcode:2001CBio...11.1381J. doi: 10.1016/S0960-9822(01)00419-5 . PMID 11566096.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000269405 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009941 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11073998-5] 1 2 Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553 . PMID 11073998.

[pmid11279525-6] Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID 11279525. S2CID 14200121.

[entrez-7] 1 2 "Entrez Gene: NXF2 nuclear RNA export factor 2".

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NXF2

Contents

Function

Interactions

Related Research Articles

References

Further reading