NXT1

NXT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JKG, 1JN5, 4WYK
Identifiers
Aliases	NXT1 , MTR2, P15, nuclear transport factor 2 like export factor 1
External IDs	OMIM: 605811 MGI: 1929619 HomoloGene: 8301 GeneCards: NXT1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,354,771 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	148,517,947 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; popliteal artery; ; mucosa of urinary bladder; ; ascending aorta; ; skin of abdomen; ; left coronary artery; ; canal of the cervix; ; periodontal fiber; ; islet of Langerhans; ; vena cava;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; medullary collecting duct; ; renal corpuscle; ; maxillary prominence; ; medial ganglionic eminence; ; otic placode; ; endocardial cushion; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	nucleus ; nuclear speck ; nuclear pore ; nucleoplasm ; cytoplasm ; cytosol ; nuclear pore central transport channel ;
Biological process	protein export from nucleus ; protein transport ; RNA export from nucleus ; mRNA export from nucleus ; protein import into nucleus ; nucleocytoplasmic transport ;
	Sources:Amigo / QuickGO
Orthologs
	29107
	56488
	ENSG00000132661
	ENSMUSG00000036992
	Q9UKK6
	Q9QZV9
	NM_013248
	NM_001110159 ; NM_019761
	NP_037380
	NP_001103629 ; NP_062735
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.^[5]^[6]^[7]

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.^[7]

Related Research Articles

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.

Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the NXF1 gene.

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Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.

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Arf-GAP domain and FG repeat-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene.

mRNA export factor is a protein that in humans is encoded by the RAE1 gene.

Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene.

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

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Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.

Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene.

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.

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The TREX (TRanscription-EXport) complex is a conserved eukaryotic multi-protein complex that couples mRNA transcription and nuclear export. The TREX complex travels across transcribed genes with RNA polymerase II. TREX binds mRNA and recruits transport proteins NXF1 and NXT1, which shuttle the mRNA out of the nucleus. The TREX complex plays an important role in genome stability and neurodegenerative diseases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132661 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036992 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Black BE, Levesque L, Holaska JM, et al. (Jan 2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol Cell Biol. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC 84993 . PMID 10567585.
↑ Guzik BW, Levesque L, Prasad S, et al. (Mar 2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol Cell Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMC 86886 . PMID 11259602.
1 2 "Entrez Gene: NXT1 NTF2-like export factor 1".

Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–609. doi:10.1093/emboj/18.9.2593. PMC 1171339 . PMID 10228171.
Ossareh-Nazari B, Maison C, Black BE, et al. (2000). "RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro". Mol. Cell. Biol. 20 (13): 4562–71. doi:10.1128/MCB.20.13.4562-4571.2000. PMC 85847 . PMID 10848583.
Herold A, Suyama M, Rodrigues JP, et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol. Cell. Biol. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553 . PMID 11073998.
Black BE, Holaska JM, Lévesque L, et al. (2001). "NXT1 is necessary for the terminal step of Crm1-mediated nuclear export". J. Cell Biol. 152 (1): 141–55. doi:10.1083/jcb.152.1.141. PMC 2193657 . PMID 11149927.
Jun L, Frints S, Duhamel H, et al. (2002). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Curr. Biol. 11 (18): 1381–91. Bibcode:2001CBio...11.1381J. doi: 10.1016/S0960-9822(01)00419-5 . PMID 11566096. S2CID 18567485.
Fribourg S, Braun IC, Izaurralde E, et al. (2001). "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor". Mol. Cell. 8 (3): 645–56. doi: 10.1016/S1097-2765(01)00348-3 . PMID 11583626.
Wiegand HL, Coburn GA, Zeng Y, et al. (2002). "Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes". Mol. Cell. Biol. 22 (1): 245–56. doi:10.1128/MCB.22.1.245-256.2002. PMC 134221 . PMID 11739738.
Katahira J, Straesser K, Saiwaki T, et al. (2002). "Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling". J. Biol. Chem. 277 (11): 9242–6. doi: 10.1074/jbc.M110007200 . PMID 11756420.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132661 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036992 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10567585-5] Black BE, Levesque L, Holaska JM, et al. (Jan 2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol Cell Biol. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC 84993 . PMID 10567585.

[pmid11259602-6] Guzik BW, Levesque L, Prasad S, et al. (Mar 2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol Cell Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMC 86886 . PMID 11259602.

[entrez-7] 1 2 "Entrez Gene: NXT1 NTF2-like export factor 1".

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NXT1

Related Research Articles

References

Further reading