Nanoknife

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Scanning electron micrograph of a nanoknife. An individual carbon nanotube is being stretched between two tungsten needles. The triangular tip is an atomic force cantilever, measuring the knife's breaking point.(NIST) Nanoknife.jpg
Scanning electron micrograph of a nanoknife. An individual carbon nanotube is being stretched between two tungsten needles. The triangular tip is an atomic force cantilever, measuring the knife's breaking point.(NIST)

A nanoknife is a carbon nanotube-based prototype compression cutting tool intended for sectioning of biological cells. [1] Working principle is similar to that of a 'cheese slicer'[ citation needed ], a nanometer-thin individual carbon nanotube strung between two tungsten needles would allow sectioning of very thin slices of biological matter for imaging under an electron microscope. Tests are currently being performed by scientists at Virginia Tech, CU-Boulder and other universities. [2] [3] A successful development of this new tool will allow scientists and biologists to make 3D images of cells and tissues for electron tomography, which typically requires samples less than ~300 nanometers in thickness. [2] In 2009, the nano-knife was used to create indentation marks on biological cell plasticizer (epoxy resin). [4] The whole cutting process is currently limited by electron charging of polymeric specimen in the SEM, which makes it difficult to observe any small cut or mark as the carbon nanotube is pressed against the specimen.

Nanoknife Procedure

Doctors use a special medical device designed for the specific purpose of performing irreversible electroporation. The device implements a direct current generator which emits short pulses of high voltage electric current through electrodes into the cell membrane. The doctor inserts thin needles into the area, using ultrasound imaging to guide the placement of the needles. In nanoknife treatment, strong electric fields cause cells to die without exposing the tissue to radiation or heating it. [5] Most patients don’t feel anything at all during the procedure.

Related Research Articles

Carbon nanotube Allotropes of carbon with a cylindrical nanostructure

Carbon nanotubes (CNTs) are tubes made of carbon with diameters typically measured in nanometers.

Electron microscope Type of microscope with electrons as a source of illumination

An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a higher resolving power than light microscopes and can reveal the structure of smaller objects. A scanning transmission electron microscope has achieved better than 50 pm resolution in annular dark-field imaging mode and magnifications of up to about 10,000,000× whereas most light microscopes are limited by diffraction to about 200 nm resolution and useful magnifications below 2000×.

Nanotechnology Field of applied science whose theme is the control of matter on atomic and (supra)molecular scale

Nanotechnology, also shortened to nanotech, is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The earliest, widespread description of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabrication of macroscale products, also now referred to as molecular nanotechnology. A more generalized description of nanotechnology was subsequently established by the National Nanotechnology Initiative, which defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers. This definition reflects the fact that quantum mechanical effects are important at this quantum-realm scale, and so the definition shifted from a particular technological goal to a research category inclusive of all types of research and technologies that deal with the special properties of matter which occur below the given size threshold. It is therefore common to see the plural form "nanotechnologies" as well as "nanoscale technologies" to refer to the broad range of research and applications whose common trait is size.

Transmission electron microscopy Technique in microscopy

Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a sensor such as a scintillator attached to a charge-coupled device.

Nanoelectromechanical systems

Nanoelectromechanical systems (NEMS) are a class of devices integrating electrical and mechanical functionality on the nanoscale. NEMS form the next logical miniaturization step from so-called microelectromechanical systems, or MEMS devices. NEMS typically integrate transistor-like nanoelectronics with mechanical actuators, pumps, or motors, and may thereby form physical, biological, and chemical sensors. The name derives from typical device dimensions in the nanometer range, leading to low mass, high mechanical resonance frequencies, potentially large quantum mechanical effects such as zero point motion, and a high surface-to-volume ratio useful for surface-based sensing mechanisms. Applications include accelerometers and sensors to detect chemical substances in the air.

A microtome is a cutting tool used to produce extremely thin slices of material known as sections. Important in science, microtomes are used in microscopy, allowing for the preparation of samples for observation under transmitted light or electron radiation.

Focused ion beam Device

Focused ion beam, also known as FIB, is a technique used particularly in the semiconductor industry, materials science and increasingly in the biological field for site-specific analysis, deposition, and ablation of materials. A FIB setup is a scientific instrument that resembles a scanning electron microscope (SEM). However, while the SEM uses a focused beam of electrons to image the sample in the chamber, a FIB setup uses a focused beam of ions instead. FIB can also be incorporated in a system with both electron and ion beam columns, allowing the same feature to be investigated using either of the beams. FIB should not be confused with using a beam of focused ions for direct write lithography. These are generally quite different systems where the material is modified by other mechanisms.

Carbon nanofiber

Carbon nanofibers (CNFs), vapor grown carbon fibers (VGCFs), or vapor grown carbon nanofibers (VGCNFs) are cylindrical nanostructures with graphene layers arranged as stacked cones, cups or plates. Carbon nanofibers with graphene layers wrapped into perfect cylinders are called carbon nanotubes.

Nanochemistry is the combination of chemistry and nano science. Nanochemistry is associated with synthesis of building blocks which are dependent on size, surface, shape and defect properties. Nanochemistry is being used in chemical, materials and physical, science as well as engineering, biological and medical applications. Nanochemistry and other nanoscience fields have the same core concepts but the usages of those concepts are different.

Potential applications of carbon nanotubes

Carbon nanotubes (CNTs) are cylinders of one or more layers of graphene (lattice). Diameters of single-walled carbon nanotubes (SWNTs) and multi-walled carbon nanotubes (MWNTs) are typically 0.8 to 2 nm and 5 to 20 nm, respectively, although MWNT diameters can exceed 100 nm. CNT lengths range from less than 100 nm to 0.5 m.

Nanoelectronics refers to the use of nanotechnology in electronic components. The term covers a diverse set of devices and materials, with the common characteristic that they are so small that inter-atomic interactions and quantum mechanical properties need to be studied extensively. Some of these candidates include: hybrid molecular/semiconductor electronics, one-dimensional nanotubes/nanowires or advanced molecular electronics.

Nanocircuits are electrical circuits operating on the nanometer scale. This is well into the quantum realm, where quantum mechanical effects become very important. One nanometer is equal to 10−9 meters or a row of 10 hydrogen atoms. With such progressively smaller circuits, more can be fitted on a computer chip. This allows faster and more complex functions using less power. Nanocircuits are composed of three different fundamental components. These are transistors, interconnections, and architecture, all fabricated on the nanometer scale.

The following outline is provided as an overview of and topical guide to nanotechnology:

A nanoradio is a nanotechnology acting as a radio transmitter and receiver by using carbon nanotubes. One of the first nanoradios was constructed in 2007 by researchers under Alex Zettl at the University of California, Berkeley where they successfully transmitted an audio signal. Due to the small size, nanoradios can have several possible applications such as radio function in the bloodstream.

Timothy S. Fisher is an American educator, engineer and expert in the application of nanotechnologies. He is a former professor of mechanical engineering at the School of Mechanical Engineering, Purdue University and Director, Nanoscale Transport Research Group-Purdue University. He currently teaches at the University of California, Los Angeles. He took his Bachelor of Science and doctorate at Cornell University in 1991 and 1998, respectively. Fisher became the chair of mechanical and aerospace engineering department at University of California, Los Angeles, starting July 1, 2018.

The nano guitar is a microscopically small carved guitar. It was developed by Dustin W. Carr in 1997, under the direction of Professor Harold G. Craighead, in the Cornell Nanofabrication Facility. The idea came about as a fun way to illustrate nanotechnology, and captured popular attention. It is disputed as to whether the nano guitar should be classified as a guitar, but it is the common opinion that it is in fact a guitar.

A carbon nanotube field-effect transistor (CNTFET) is a field-effect transistor that utilizes a single carbon nanotube or an array of carbon nanotubes as the channel material instead of bulk silicon in the traditional MOSFET structure. First demonstrated in 1998, there have been major developments in CNTFETs since.

The applications of nanotechnology, commonly incorporate industrial, medicinal, and energy uses. These include more durable construction materials, therapeutic drug delivery, and higher density hydrogen fuel cells that are environmentally friendly. Being that nanoparticles and nanodevices are highly versatile through modification of their physiochemical properties, they have found uses in nanoscale electronics, cancer treatments, vaccines, hydrogen fuel cells, and nanographene batteries.

In situ electron microscopy is an investigatory technique where an electron microscope is used to watch a sample's response to a stimulus in real time. Due to the nature of the high-energy beam of electrons used to image a sample in an electron microscope, microscopists have long observed that specimens are routinely changed or damaged by the electron beam. Starting in the 1960s, and using transmission electron microscopes (TEMs), scientists made deliberate attempts to modify materials while the sample was in the specimen chamber, and to capture images through time of the induced damages.

This glossary of nanotechnology is a list of definitions of terms and concepts relevant to nanotechnology, its sub-disciplines, and related fields.

References

  1. On the Cutting Edge: Carbon Nanotube Cutlery, National Institute of Standards and Technology, 22 November 2006, retrieved 2010-03-19
  2. 1 2 G Singh; P Rice; R L Mahajan; J R McIntosh (11 February 2009), "Fabrication and characterization of a carbon nanotube-based nanoknife", Nanotechnology, 20 (9): 095701, Bibcode:2009Nanot..20i5701S, doi:10.1088/0957-4484/20/9/095701, PMC   2879632 , PMID   19417497
  3. "Nanodevices Using Individual Carbon nanotubes", NanoScience and Engineering Group, Kansas State University , retrieved 2010-03-19[ permanent dead link ]
  4. "Spotlight", Cutting edge nanotechnology, Nanowerk, 18 February 2009, retrieved 2010-03-19
  5. "Nanoknife | Innovative Prostate Cancer Treatment | Vitus Prostate Center". Vitus Prostate. Retrieved 2018-09-18.