Nasal embryonic LHRH factor

NSMF
Identifiers
Aliases	NSMF , HH9, NELF, Nasal embryonic LHRH factor, NMDA receptor synaptonuclear signaling and neuronal migration factor
External IDs	OMIM: 608137; MGI: 1861755; HomoloGene: 10648; GeneCards: NSMF; OMA:NSMF - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 137,447,570 bp [1] End 137,459,334 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 24,944,367 bp [2] End 24,952,893 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior cingulate cortex right frontal lobe amygdala prefrontal cortex Region I of hippocampus proper ascending aorta dorsolateral prefrontal cortex caudate nucleus Descending thoracic aorta nucleus accumbens Top expressed in medial dorsal nucleus medial geniculate nucleus lateral geniculate nucleus subiculum anterior amygdaloid area barrel cortex suprachiasmatic nucleus substantia nigra olfactory tubercle prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent protein binding Cellular component cytoplasm apical dendrite perikaryon postsynaptic membrane cell projection nuclear membrane nuclear envelope membrane postsynaptic density nuclear matrix cortical cytoskeleton plasma membrane synapse nucleoplasm cell junction dendrite cell cortex neuron projection cytoskeleton nucleus Biological process positive regulation of protein dephosphorylation regulation of neuron apoptotic process positive regulation of neuron migration regulation of dendrite morphogenesis cellular response to amino acid stimulus cellular response to gonadotropin stimulus cellular response to electrical stimulus regulation of neuron migration regulation of neuronal synaptic plasticity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26012 56876 Ensembl ENSG00000165802 ENSMUSG00000006476 UniProt Q6X4W1 Q99NF2 RefSeq (mRNA) NM_001130969 NM_001130970 NM_001130971 NM_001178064 NM_015537 NM_001039386 NM_001039387 NM_001177654 NM_001177655 NM_020276 RefSeq (protein) NP_001124441 NP_001124442 NP_001124443 NP_001171535 NP_056352 NP_001034475 NP_001034476 NP_001171125 NP_001171126 NP_064672 Location (UCSC) Chr 9: 137.45 – 137.46 Mb Chr 2: 24.94 – 24.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000165802 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006476 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development. 14 (14): 1824–34. doi:10.1101/gad.14.14.1824. PMC   316793 . PMID   10898796.
7. "Entrez Gene: NELF nasal embryonic LHRH factor".

Further reading

• Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)". Journal of Human Genetics. 49 (5): 265–8. doi: 10.1007/s10038-004-0137-4 . PMID   15362570.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.