Neutron stimulated emission computed tomography

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Neutron stimulated emission computed tomography
Purposedetecting liver iron overload disorders

Neutron stimulated emission computed tomography (NSECT) uses induced gamma emission through neutron inelastic scattering to generate images of the spatial distribution of elements in a sample. [1]

Contents

Clinical Applications

NSECT has been shown to be effective in detecting liver iron overload disorders [2] and breast cancer. [3] Due to its sensitivity in measuring elemental concentrations, NSECT is currently being developed for cancer staging, among other medical applications.

NSECT mechanism

A given atomic nucleus, defined by its proton and neutron numbers, is a quantized system with a set of characteristic higher energy levels that it can occupy as a nuclear isomer. When the nucleus in its ground state is struck by a fast neutron with kinetic energy greater than that of its first excited state, it can undergo an isomeric transition to one of its excited states by receiving the necessary energy from the fast neutron through inelastic scatter. Promptly (on the order of picoseconds, on average) after excitation, the excited nuclear isomer de-excites (either directly or through a series of cascades) to the ground state, emitting a characteristic gamma ray for each decay transition with energy equal to the difference in the energy levels involved (see induced gamma emission). After irradiating the sample with neutrons, the measured number of emitted gamma rays of energy characteristic to the nucleus of interest is directly proportional to the number of such nuclei along the incident neutron beam trajectory. After repeating the measurement for neutron beam incidence at positions around the sample, an image of the distribution of the nuclei in the sample can be reconstructed as done in tomography.

Related Research Articles

<span class="mw-page-title-main">Neutron</span> Subatomic particle with no charge

The neutron is a subatomic particle, symbol
n
or
n0
, which has a neutral charge, and a mass slightly greater than that of a proton. Protons and neutrons constitute the nuclei of atoms. Since protons and neutrons behave similarly within the nucleus, and each has a mass of approximately one dalton, they are both referred to as nucleons. Their properties and interactions are described by nuclear physics. Protons and neutrons are not elementary particles; each is composed of three quarks.

<span class="mw-page-title-main">Nuclear physics</span> Field of physics that studies atomic nuclei

Nuclear physics is the field of physics that studies atomic nuclei and their constituents and interactions, in addition to the study of other forms of nuclear matter.

<span class="mw-page-title-main">Nuclear isomer</span> Metastable excited state of a nuclide

A nuclear isomer is a metastable state of an atomic nucleus, in which one or more nucleons (protons or neutrons) occupy higher energy levels than in the ground state of the same nucleus. "Metastable" describes nuclei whose excited states have half-lives 100 to 1000 times longer than the half-lives of the excited nuclear states that decay with a "prompt" half life (ordinarily on the order of 10−12 seconds). The term "metastable" is usually restricted to isomers with half-lives of 10−9 seconds or longer. Some references recommend 5 × 10−9 seconds to distinguish the metastable half life from the normal "prompt" gamma-emission half-life. Occasionally the half-lives are far longer than this and can last minutes, hours, or years. For example, the 180m
73
Ta
nuclear isomer survives so long (at least 1015 years) that it has never been observed to decay spontaneously. The half-life of a nuclear isomer can even exceed that of the ground state of the same nuclide, as shown by 180m
73
Ta
as well as 192m2
77
Ir
, 210m
83
Bi
, 242m
95
Am
and multiple holmium isomers.

Ionizing radiation, including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. Some particles can travel up to 99% of the speed of light, and the electromagnetic waves are on the high-energy portion of the electromagnetic spectrum.

<span class="mw-page-title-main">Proton emission</span> Type of radioactive decay

Proton emission is a rare type of radioactive decay in which a proton is ejected from a nucleus. Proton emission can occur from high-lying excited states in a nucleus following a beta decay, in which case the process is known as beta-delayed proton emission, or can occur from the ground state of very proton-rich nuclei, in which case the process is very similar to alpha decay. For a proton to escape a nucleus, the proton separation energy must be negative —the proton is therefore unbound, and tunnels out of the nucleus in a finite time. The rate of proton emission is governed by the nuclear, Coulomb, and centrifugal potentials of the nucleus, where centrifugal potential affects a large part of the rate of proton emission. Half-life of proton emission is affected by the proton energy and its orbital angular momentum. Proton emission is not seen in naturally occurring isotopes; proton emitters can be produced via nuclear reactions, usually using linear particle accelerators.

<span class="mw-page-title-main">Neutron emission</span> Type of radioactive decay

Neutron emission is a mode of radioactive decay in which one or more neutrons are ejected from a nucleus. It occurs in the most neutron-rich/proton-deficient nuclides, and also from excited states of other nuclides as in photoneutron emission and beta-delayed neutron emission. As only a neutron is lost by this process the number of protons remains unchanged, and an atom does not become an atom of a different element, but a different isotope of the same element.

<span class="mw-page-title-main">Neutron radiation</span> Ionizing radiation that presents as free neutrons

Neutron radiation is a form of ionizing radiation that presents as free neutrons. Typical phenomena are nuclear fission or nuclear fusion causing the release of free neutrons, which then react with nuclei of other atoms to form new nuclides—which, in turn, may trigger further neutron radiation. Free neutrons are unstable, decaying into a proton, an electron, plus an electron antineutrino. Free neutrons have a mean lifetime of 887 seconds.

<span class="mw-page-title-main">Nuclear reaction</span> Process in which two nuclei collide to produce one or more nuclides

In nuclear physics and nuclear chemistry, a nuclear reaction is a process in which two nuclei, or a nucleus and an external subatomic particle, collide to produce one or more new nuclides. Thus, a nuclear reaction must cause a transformation of at least one nuclide to another. If a nucleus interacts with another nucleus or particle and they then separate without changing the nature of any nuclide, the process is simply referred to as a type of nuclear scattering, rather than a nuclear reaction.

<span class="mw-page-title-main">Neutron scattering</span> Physical phenomenon

Neutron scattering, the irregular dispersal of free neutrons by matter, can refer to either the naturally occurring physical process itself or to the man-made experimental techniques that use the natural process for investigating materials. The natural/physical phenomenon is of elemental importance in nuclear engineering and the nuclear sciences. Regarding the experimental technique, understanding and manipulating neutron scattering is fundamental to the applications used in crystallography, physics, physical chemistry, biophysics, and materials research.

In chemistry, nuclear physics, and particle physics, inelastic scattering is a fundamental scattering process in which the kinetic energy of an incident particle is not conserved. In an inelastic scattering process, some of the energy of the incident particle is lost or increased. Although the term is historically related to the concept of inelastic collision in dynamics, the two concepts are quite distinct; inelastic collision in dynamics refers to processes in which the total macroscopic kinetic energy is not conserved. In general, scattering due to inelastic collisions will be inelastic, but, since elastic collisions often transfer kinetic energy between particles, scattering due to elastic collisions can also be inelastic, as in Compton scattering meaning the two particles in the collision transfer energy causing a loss of energy in one particle.

The nuclear cross section of a nucleus is used to describe the probability that a nuclear reaction will occur. The concept of a nuclear cross section can be quantified physically in terms of "characteristic area" where a larger area means a larger probability of interaction. The standard unit for measuring a nuclear cross section is the barn, which is equal to 10−28 m2, 10−24 cm2 or 100 fm2. Cross sections can be measured for all possible interaction processes together, in which case they are called total cross sections, or for specific processes, distinguishing elastic scattering and inelastic scattering; of the latter, amongst neutron cross sections the absorption cross sections are of particular interest.

Technetium (43Tc) is one of the two elements with Z < 83 that have no stable isotopes; the other such element is promethium. It is primarily artificial, with only trace quantities existing in nature produced by spontaneous fission or neutron capture by molybdenum. The first isotopes to be synthesized were 97Tc and 99Tc in 1936, the first artificial element to be produced. The most stable radioisotopes are 97Tc, 98Tc, and 99Tc.

Natural nitrogen (7N) consists of two stable isotopes: the vast majority (99.6%) of naturally occurring nitrogen is nitrogen-14, with the remainder being nitrogen-15. Fourteen radioisotopes are also known, with atomic masses ranging from 10 to 25, along with one nuclear isomer, 11mN. All of these radioisotopes are short-lived, the longest-lived being nitrogen-13 with a half-life of 9.965(4) min. All of the others have half-lives below 7.15 seconds, with most of these being below 620 milliseconds. Most of the isotopes with atomic mass numbers below 14 decay to isotopes of carbon, while most of the isotopes with masses above 15 decay to isotopes of oxygen. The shortest-lived known isotope is nitrogen-10, with a half-life of 143(36) yoctoseconds.

Yrast is a technical term in nuclear physics that refers to a state of a nucleus with a minimum of energy for a given angular momentum. Yr is a Swedish adjective sharing the same root as the English whirl. Yrast is the superlative of yr and can be translated whirlingest, although it literally means "dizziest" or "most bewildered". The yrast levels are vital to understanding reactions, such as off-center heavy ion collisions, that result in high-spin states.

<span class="mw-page-title-main">Mössbauer spectroscopy</span> Spectroscopic technique

Mössbauer spectroscopy is a spectroscopic technique based on the Mössbauer effect. This effect, discovered by Rudolf Mössbauer in 1958, consists of the nearly recoil-free emission and absorption of nuclear gamma rays in solids. The consequent nuclear spectroscopy method is exquisitely sensitive to small changes in the chemical environment of certain nuclei.

In atomic physics, giant resonance is a high-frequency collective excitation of atomic nuclei, as a property of many-body quantum systems. In the macroscopic interpretation of such an excitation in terms of an oscillation, the most prominent giant resonance is a collective oscillation of all protons against all neutrons in a nucleus.

<span class="mw-page-title-main">Gamma ray</span> Energetic electromagnetic radiation arising from radioactive decay of atomic nuclei

A gamma ray, also known as gamma radiation (symbol γ or ), is a penetrating form of electromagnetic radiation arising from the radioactive decay of atomic nuclei. It consists of the shortest wavelength electromagnetic waves, typically shorter than those of X-rays. With frequencies above 30 exahertz (3×1019 Hz), it imparts the highest photon energy. Paul Villard, a French chemist and physicist, discovered gamma radiation in 1900 while studying radiation emitted by radium. In 1903, Ernest Rutherford named this radiation gamma rays based on their relatively strong penetration of matter; in 1900 he had already named two less penetrating types of decay radiation (discovered by Henri Becquerel) alpha rays and beta rays in ascending order of penetrating power.

The isomeric shift is the shift on atomic spectral lines and gamma spectral lines, which occurs as a consequence of replacement of one nuclear isomer by another. It is usually called isomeric shift on atomic spectral lines and Mössbauer isomeric shift respectively. If the spectra also have hyperfine structure the shift refers to the center of gravity of the spectra. The isomeric shift provides important information about the nuclear structure and the physical, chemical or biological environment of atoms. More recently the effect has also been proposed as a tool in the search for the time variation of fundamental constants of nature.

A gamma-ray laser, or graser, is a hypothetical device that would produce coherent gamma rays, just as an ordinary laser produces coherent rays of visible light. Potential applications for gamma-ray lasers include medical imaging, spacecraft propulsion, and cancer treatment.

References

  1. Kapadia, Anuj (2009). "Neutron Stimulated Emission Computed Tomography: A New Technique for Spectroscopic Medical Imaging". Neutron Imaging and Applications. Neutron Scattering Applications and Techniques. pp. 265–288. doi:10.1007/978-0-387-78693-3_15. ISBN   978-0-387-78692-6.
  2. Kapadia, Anuj (2007). Accuracy and patient dose in neutron stimulated emission computed tomography for diagnosis of iron overload: Simulations in GEANT4. Durham, NC: Duke University.
  3. Kapadia, Anuj; Sharma, Amy C.; Georgia Tourassi; Bender, Janelle E.; Howell, Calvin R.; Crowell, Alexander S.; Kiser, Matthew R.; Harrawood, Brian P.; Pedroni, Ronald S.; Floyd Jr, Carey E. (2008). "Neutron Stimulated Emission Computed Tomography for Diagnosis of Breast Cancer". IEEE Transactions on Nuclear Science. 55 (1): 501–509. Bibcode:2008ITNS...55..501K. CiteSeerX   10.1.1.660.9231 . doi:10.1109/TNS.2007.909847. S2CID   11928052.

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