U.S. Route 395, also known as U.S. Highway 395, is a north–south United States Numbered Highway that traverses the inland areas of the western states of California, Nevada, Oregon, and Washington. It travels for over 1,300 miles (2,100 km) from a junction in the Mojave Desert at Interstate 15 (I-15) in Hesperia to the Canada–U.S. border near Laurier, Washington. Major cities along its route include Carson City and Reno in Nevada; Kennewick and Pasco in Washington's Tri-Cities region; and Spokane, Washington. US 395 is an auxiliary route of US 95 but never intersects its parent route, which runs further east.
Interstate 515 (I-515) is a 14.44-mile-long (23.24 km) spur route of I-15 in the US state of Nevada that runs from the junction of I-11, I-215, and State Route 564 (SR 564) at the Spaghetti Bowl Interchange in Henderson to the junction of I-15, U.S. Route 93 (US 93), and US 95 at the Las Vegas Spaghetti Bowl Interchange in Downtown Las Vegas. The freeway connects traffic headed from Boulder City and Henderson to Downtown Las Vegas via a direct, high-speed route, and it runs concurrently with, US 93, and US 95 along its entire length.
State Route 377 is a 6.6-mile (10.6 km) state highway in Nye County, Nevada, United States. The route connects the town of Manhattan to State Route 376. The highway previously existed as State Route 69.
State Route 28 (SR 28) is a 16.3-mile (26.2 km) state highway in Douglas County, Carson City, and Washoe County in western Nevada, United States, that runs along the northeastern shore of Lake Tahoe. SR 28 connects U.S. Route 50 (US 50) in Douglas County with California State Route 28 at Crystal Bay. SR 28 has been part of the Nevada scenic byway system since June 1994 and the National Scenic Byway system since September 1996.
State Route 207 (SR 207) is an 11.082-mile (17.835 km) state highway in western Douglas County, Nevada, United States. Commonly known as the Kingsbury Grade, it is one of three Nevada highways that connect the western edge of the state to the Lake Tahoe region through the Carson Range. The route was part of State Route 19 prior to 1976.
U.S. Route 50 (US 50) is a transcontinental highway in the United States, stretching from West Sacramento, California, in the west to Ocean City, Maryland, on the east coast. The Nevada portion crosses the center of the state and was named "The Loneliest Road in America" by Life magazine in July 1986. The name was intended as a pejorative, but Nevada officials seized it as a marketing slogan. The name originates from large desolate areas traversed by the route, with few or no signs of civilization. The highway crosses several large desert valleys separated by numerous mountain ranges towering over the valley floors, in what is known as the Basin and Range province of the Great Basin.
State Route 305 is a state highway in Lander County, Nevada. It is the only state highway to connect the southern and northern areas of the county. It runs north from U.S. Route 50 at Austin to Battle Mountain, where it crosses Interstate 80 and ends at State Route 304.
State Route 306 is a 30.631-mile (49.296 km) state highway in Lander and Eureka counties in northern Nevada, United States. It connects the mining area of Gold Acres in Lander County to Interstate 80 (I-80) at the Beowawe Interchange near Beowawe in Eureka County via Crescent Valley. The road has been a state highway since the 1920s, having been established as part of a much longer State Route 21 by 1929.
U.S. Route 50 (US 50) is a transcontinental United States Numbered Highway, stretching from West Sacramento, California, in the west to Ocean City, Maryland, in the east. The California portion of US 50 runs east from Interstate 80 (I-80) in West Sacramento to the Nevada state line in South Lake Tahoe. A portion in Sacramento also has the unsigned designation of Interstate 305. The western half of the highway in California is a four-or-more-lane divided highway, mostly built to freeway standards, and known as the El Dorado Freeway outside of downtown Sacramento. US 50 continues as an undivided highway with one eastbound lane and two westbound lanes until the route reaches the canyon of the South Fork American River at Riverton. The remainder of the highway, which climbs along and out of the canyon, then over the Sierra Nevada at Echo Summit and into the Lake Tahoe Basin, is primarily a two-lane road.
State Route 376 is a 100-mile (160 km) state highway in Nye and Lander counties in central Nevada, United States. It connects U.S. Route 6 near Tonopah north to U.S. Route 50 near Austin. The Tonopah–Austin Road existed as early as 1919, and was designated the southernmost segment of State Route 8A before being renumbered to SR 376 in 1976.
State Route 564 is an east–west highway in Clark County, Nevada, in the southeast portion of the Las Vegas Valley. The route travels through the city of Henderson, traveling from the junction of Interstate 215 (I-215) and I-11 south and I-515 north, also part of U.S. Route 93 and US 95, to Lake Las Vegas, ending near Lake Mead. The route was designated in 2002, replacing a portion of SR 146.
State Route 487 is a north–south state highway in White Pine County, Nevada. The route follows Baker Road from the Utah–Nevada state line southeast of Baker to U.S. Route 6 and U.S. Route 50. The route was previously known as State Route 73 prior to 1976. SR 487 is designated as a Nevada Scenic Byway.
State Route 379 covers Duckwater Road, a 19.532-mile (31.434 km) state highway in Nye County, Nevada, United States. The route serves the Duckwater Indian Reservation, connecting the community of Duckwater to U.S. Route 6 at Currant. The highway was formerly a part of State Route 20 prior to the 1970s.
State Route 513 was a short state highway in Carson City, Nevada. The route was originally part of State Route 65, a longer highway that served the eastern outskirts of the city. SR 513 was turned over to Carson City in phases, and completely removed from the state highway system in 2011.
Interstate 80 Business is an unofficial business loop of Interstate 80 (I-80) that is 2.26 miles (3.64 km) long and serves as the main street for the US cities of West Wendover, Nevada, and Wendover, Utah, along a roadway named Wendover Boulevard. Wendover Boulevard was originally part of US Route 40 (US 40), which connected California to New Jersey via Nevada and Utah. A portion of the Nevada segment is concurrent with US 93 Alternate, and the entire portion in Utah is coterminous with Utah State Route 58 (SR-58). The Nevada Department of Transportation (NDOT) applied for the business loop designation in the early 1980s, but the designation has never been approved; nevertheless, signs are posted in both states. Between July 1976 and 1993, I-80 Bus was concurrent with Nevada State Route 224 (SR 224) in Nevada.
U.S. Route 395 (US 395) is an 85-mile-long (137 km) United States Numbered Highway near Lake Tahoe in the state of Nevada. It traverses the state after entering from California in Topaz Lake and crosses back into California near Hallelujah Junction. US 395 serves the cities of Gardnerville, Minden, Carson City and Reno. All of US 395 north of Carson City is a freeway and is built up to Interstate Highway standards. Part of the freeway section is also designated as Interstate 580 (I-580). US 395 is an important regional highway, serving the communities of Western Nevada, connecting them to other major communities via California, and it is the only major north–south arterial for the geographically isolated region.
State Route 396 is a state highway in Pershing County, Nevada serving the city of Lovelock. The highway forms a portion of Interstate 80 Business within the city of Lovelock, and previously carried the alignment of former U.S. Route 40 and U.S. Route 95.
Several special routes of U.S. Route 19 (US 19) exist. In order from south to north, they are as follows.
SR 8A 
US 50 
