Nolatrexed

Nolatrexed
Names
	Preferred IUPAC name 2-Amino-6-methyl-5-[(pyridin-4-yl)sulfanyl]quinazolin-4(1H)-one
Identifiers
CAS Number	147149-76-6 ;
3D model (JSmol)	Interactive image ;
ChemSpider	97268 ;
PubChem CID	108189 ;
UNII	K75ZUN743Q ;
CompTox Dashboard (EPA)	DTXSID3048281 ;
	InChI InChI=1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19) Key: XHWRWCSCBDLOLM-UHFFFAOYSA-N ; InChI=1/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19) Key: XHWRWCSCBDLOLM-UHFFFAOYAK;
	SMILES CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3;
Properties
Chemical formula	C14H12N4OS
Molar mass	284.34 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated July 18, 2025

Nolatrexed is a thymidylate synthase inhibitor.^[1]^[2]

References

↑ Hughes AN, Rafi I, Griffin MJ, et al. (January 1999). "Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days". Clin. Cancer Res. 5 (1): 111–8. PMID 9918208.
↑ "Nolatrexed". PubChem.gov. Pub Chem. Retrieved 12 August 2014.

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[pmid9918208-1] Hughes AN, Rafi I, Griffin MJ, et al. (January 1999). "Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days". Clin. Cancer Res. 5 (1): 111–8. PMID 9918208.

[2] "Nolatrexed". PubChem.gov. Pub Chem. Retrieved 12 August 2014.

[1]

[2]

Names

Preferred IUPAC name 2-Amino-6-methyl-5-[(pyridin-4-yl)sulfanyl]quinazolin-4(1H)-one
Identifiers
CAS Number	147149-76-6 ^Y
3D model (JSmol)	Interactive image
ChemSpider	97268 ^N
PubChem CID	108189
UNII	K75ZUN743Q ^Y
CompTox Dashboard (EPA)	DTXSID3048281
InChI InChI=1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)^N Key: XHWRWCSCBDLOLM-UHFFFAOYSA-N^N InChI=1/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19) Key: XHWRWCSCBDLOLM-UHFFFAOYAK
SMILES CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3
Properties
Chemical formula	C₁₄H₁₂N₄OS
Molar mass	284.34 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references