U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
North Carolina Highway 75 (NC 75) is a primary state highway in the U.S. state of North Carolina. Its entire length runs through Union County and serves as the primary connector between the towns of Waxhaw, Mineral Springs, and Monroe. The route roughly parallels a CSX railroad line for its entire span.
North Carolina Highway 83 (NC 83) is a primary state highway in the U.S. state of North Carolina. It serves to connect the towns of Maxton and Clio, South Carolina.
North Carolina Highway 7 (NC 7) is a primary state highway in the U.S. state of North Carolina. Entirely within Gaston County, it connects the towns of Lowell, McAdenville, and Belmont with the city of Gastonia.
North Carolina Highway 226 (NC 226) is a primary state highway in the U.S. state of North Carolina. Traveling north–south through Western North Carolina, it connects the cities and towns of Grover, Shelby, Marion, Spruce Pine and Bakersville. It also a scenic byway in the South Mountains area and connects with the summer colony of Little Switzerland, via NC 226A.
North Carolina Highway 8 (NC 8) is a primary state highway in the U.S. state of North Carolina. The route connects the cities of Lexington and Winston-Salem to various recreational and natural sites including Uwharrie National Forest, High Rock Lake and Hanging Rock State Park. NC 8 is part of a two-state, 151 mile highway 8 system.
North Carolina Highway 16 (NC 16) is a primary state highway in the U.S. state of North Carolina. Traveling north–south, it connects the cities of Charlotte, Conover, Taylorsville, Wilkesboro and Jefferson; linking the Charlotte metropolitan area with the High Country.
North Carolina Highway 345 (NC 345) is a primary state highway in the U.S. state of North Carolina connecting Wanchese and Manteo on Roanoke Island. The highway begins at The Lane and Thicket Lump Drive south of the town marina. Following Mill Landing Road through Wanchese, the road eventually becomes the western boundary for the Roanoke Island Marshes Dedicated Nature Preserve, before reaching its northern terminus at US 64.
North Carolina Highway 212 (NC 212) is a primary state highway in the U.S. state of North Carolina. The highway connects the White Rock community, through the Bald Mountains, in Madison County.
North Carolina Highway 213 (NC 213) is a primary state highway in the U.S. state of North Carolina. The highway connects Marshall with Walnut and Mars Hill.
North Carolina Highway 60 (NC 60) is a primary state highway in the extreme southwestern corner of North Carolina. The highway runs north–south from the Georgia state line to U.S. Route 64/U.S. Route 74 (US 64/US 74), near Ranger.
North Carolina Highway 143 (NC 143) is a primary state highway in the U.S. state of North Carolina. It runs from the Tennessee state line to NC 28, near the community of Stecoah. It is best known for its 18-mile (29 km) section of the Cherohala Skyway, shared with Tennessee State Route 165.
Interstate 40 (I-40) is a part of the Interstate Highway System that runs from Barstow, California to Wilmington, North Carolina. In North Carolina, I-40 enters the state along the Pigeon River Gorge, from Tennessee. Crossing the entire state, it connects the cities of Asheville, Winston-Salem, Greensboro, Durham and Raleigh before ending along U.S. Highway 117/North Carolina Highway 132 (US 117/NC 132) in Wilmington. The landscapes traversed by I-40 include the Blue Ridge Mountains, foothills of western North Carolina, suburban communities, the urban core of several Piedmont cities, along with eastern North Carolina farmland. At a total of 423.55 miles (681.64 km), it is the longest interstate highway in North Carolina. There are five auxiliary Interstates in the state related to I-40, as well as one business loop which currently runs through Winston-Salem. The route is labeled east-west for the entire route, however the eastern portion follows a much more north-south alignment.
North Carolina Highway 903 (NC 903) is a primary state highway in the U.S. state of North Carolina. It serves as predominantly rural highway in the Inner Banks region and arterial road in and around Greenville. The road covers a total of 200 miles (320 km), in a zigzag pattern through the state.
North Carolina Highway 61 (NC 61) is a primary state highway in the U.S. state of North Carolina. It serves as the main north–south highway in eastern Guilford County, connecting Whitsett and Gibsonville.
North Carolina Highway 281 (NC 281) is a primary state highway in the U.S. state of North Carolina. The highway runs north–south, connecting communities in western Jackson County and scenic areas of southwest Transylvania County. It is the only North Carolina state highway that changes numbers when crossing into South Carolina.
North Carolina Highway 209 (NC 209) is a primary state highway in the U.S. state of North Carolina. The highway runs north–south from Lake Junaluska to Hot Springs.
North Carolina Highway 180 (NC 180) is a primary state highway in the U.S. state of North Carolina. The highway serves as a bypass east of Shelby.
North Carolina Highway 138 (NC 138) is a primary state highway in the U.S. state of North Carolina. It serves to connect the community of Aquadale to nearby Oakboro and Albemarle.
North Carolina Highway 123 (NC 123) is a primary state highway in the U.S. state of North Carolina. It serves as the main road through Hookerton and an alternate bypass of Snow Hill, entirely in Greene County.
