U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina, to U.S. Route 52, in Mount Airy, North Carolina.
U.S. Route 701 is an auxiliary route of US 1 in the U.S. states of South Carolina and North Carolina. The U.S. Highway runs 171.45 miles (275.92 km) from US 17 and US 17 Alternate in Georgetown, South Carolina north to US 301, North Carolina Highway 96, and Interstate 95 (I-95) near Four Oaks, North Carolina. US 701 serves the Pee Dee region of South Carolina and the southern and central portions of Eastern North Carolina. The highway connects Georgetown and Conway in South Carolina with the North Carolina cities of Whiteville, Elizabethtown, Clinton, and a short distance north of its terminus, Smithfield. US 701 has four business routes in North Carolina, including those through Tabor City, Whiteville, Clarkton, and Clinton.
U.S. Route 176 is a spur of US 76 in the U.S. states of North Carolina and South Carolina. The U.S. Highway runs 237.98 miles (382.99 km) from US 25 Business and North Carolina Highway 225 in Hendersonville, North Carolina, east to US 52 in Goose Creek, South Carolina. US 176 serves the transition region between the Blue Ridge Mountains and Foothills of Western North Carolina and the Upstate, Midlands, and Lowcountry regions of South Carolina. The highway passes through and connects Spartanburg, one of two major cities in the Upstate, and Columbia, the South Carolina state capital and central city of the Midlands. US 176 parallels and serves as a secondary highway to Interstate 26 (I-26) except for between Spartanburg and Columbia, where the U.S. Highway deviates from the I-26 corridor to serve Union.
North Carolina Highway 24 (NC 24) is the longest primary state highway in the U.S. state of North Carolina. Traveling east–west between the Charlotte metropolitan area and the Crystal Coast, connecting the cities of Charlotte, Fayetteville, Jacksonville and Morehead City.
North Carolina Highway 51 (NC 51) is a primary state highway in the U.S. state of North Carolina entirely in Mecklenburg County. It connects the towns of Pineville, Matthews and Mint Hill.
North Carolina Highway 75 (NC 75) is a primary state highway in the U.S. state of North Carolina. Its entire length runs through Union County and serves as the primary connector between the towns of Waxhaw, Mineral Springs, and Monroe. The route roughly parallels a CSX railroad line for its entire span.
North Carolina Highway 84 (NC 84) is a primary state highway in the U.S. state of North Carolina. It serves to connect the town of Weddington to the city of Monroe.
South Carolina Highway 9 is a 258.3-mile-long (416 km) major state highway in the U.S. state of South Carolina. The route runs from North Myrtle Beach to the North Carolina border upstate. The road is currently the longest state highway in South Carolina. It is signed as a north–south highway though overall it runs in an east–west direction.
North Carolina Highway 16 (NC 16) is a primary state highway in the U.S. state of North Carolina. Traveling north–south, it connects the cities of Charlotte, Conover, Taylorsville, Wilkesboro and Jefferson; linking the Charlotte metropolitan area with the High Country.
North Carolina Highway 49 (NC 49) is a primary state highway in the U.S. state of North Carolina. It traverses much of the Piedmont region of North Carolina.
North Carolina Highway 87 (NC 87) is a primary state highway in the U.S. state of North Carolina. NC 87 begins in the Atlantic coastal town of Southport and crosses into Virginia at the Virginia state line five miles (8 km) north of Eden in Rockingham County. At 240 miles (390 km) in length, NC 87 is the second longest state highway in the U.S. state of North Carolina. Labeled as a north–south route, NC 87 travels along a relatively straight southeast–northwest path, connecting Cape Fear region with the Piedmont and connecting the cities of Fayetteville, Sanford, and Burlington.
North Carolina Highway 200 (NC 200) is a primary state highway in the U.S. state of North Carolina. The highway runs north–south from the South Carolina state line near the community of JAARS, to US 601 near Concord.
U.S. Highway 76 (US 76) is an east–west road in North Carolina running from the South Carolina state line to Wrightsville Beach. US 76 runs concurrently with US 74 for 52 miles (84 km) of the entire route in North Carolina. US 76 was first designated in North Carolina between late 1934 and 1935.
In the U.S. state of North Carolina U.S. Route 221 (US 221) is a north–south highway that travels through Western North Carolina. From Chesnee, South Carolina to Independence, Virginia, it connects the cities of Rutherfordton, Marion, Boone and Jefferson between the two out-of-state destinations. Its most memorable section, known as the Little Parkway Scenic Byway between Linville and Blowing Rock, offers area visitors a curvier alternative to the Blue Ridge Parkway and access to Grandfather Mountain.
Several special routes of U.S. Route 74 exist. In order from west to east they are as follows.
North Carolina Highway 78 (NC 78) is a primary state highway in the U.S. state of North Carolina. The highway connects the Tramway community with Sanford's Jonesboro Heights neighborhood.
South Carolina Highway 151 (SC 151) is a primary state highway in the U.S. state of South Carolina. Known as "the road to the beach", by many residents of the Charlotte metropolitan area due to it being the most direct route to the Grand Strand, it connects the Charlotte metropolitan area to Darlington, Florence, and the Grand Strand.
South Carolina Highway 207 (SC 207) is a primary state highway in the state of South Carolina. It is entirely within the boundaries of Chesterfield County and serves to connect the city of Pageland, South Carolina to the city of Monroe, North Carolina via North Carolina Highway 207 (NC 207).
South Carolina Highway 12 (SC 12) is a state highway in the U.S. state of South Carolina. It serves Columbia and areas to its east. It serves as a parallel route to Interstate 20 (I-20) for much of its length.
North Carolina Highway 410 (NC 410) is a primary state highway in the U.S. state of North Carolina. It serves as the central north–south highway in Columbus and Bladen Counties.
