U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
North Carolina Highway 740 is a primary state highway in the U.S. state of North Carolina. The main purpose of highway is to connect the town of Badin with the rest of Stanly County.
North Carolina Highway 7 (NC 7) is a primary state highway in the U.S. state of North Carolina. Entirely within Gaston County, it connects the towns of Lowell, McAdenville, and Belmont with the city of Gastonia.
North Carolina Highway 16 (NC 16) is a primary state highway in the U.S. state of North Carolina. Traveling north–south, it connects the cities of Charlotte, Conover, Taylorsville, Wilkesboro and Jefferson; linking the Charlotte metropolitan area with the High Country.
North Carolina Highway 50 (NC 50) is a primary state highway in the U.S. state of North Carolina. It traverses north–south, from Topsail Beach to Creedmoor, connecting the cities of Warsaw, Newton Grove, Benson, and Raleigh.
North Carolina Highway 49 (NC 49) is a primary state highway in the U.S. state of North Carolina. It traverses much of the Piedmont region of North Carolina.
North Carolina Highway 90 is a primary state highway in the U.S. state of North Carolina. It is one of the few highways in the state with an unpaved portion.
North Carolina Highway 97 (NC 97) is a primary state highway in the U.S. state of North Carolina, connecting the cities of Zebulon and Rocky Mount with the vast rural coastal plains.
North Carolina Highway 28 (NC 28) is an 81.2-mile-long (130.7 km) primary state highway in the U.S. state of North Carolina. The highway runs north–south through the Nantahala National Forest in Western North Carolina.
North Carolina Highway 186 (NC 186) is a primary state highway in the U.S. state of North Carolina. Entirely in Northampton County, it helps facilitate truck traffic parallel to I-95 and connect the communities of Seaboard and Margarettsville.
North Carolina Highway 62 (NC 62) is a primary state highway in the U.S. state of North Carolina. Primarily in the Piedmont Triad, it runs from NC 109 in Thomasville northeast to the Virginia state line in Milton.
North Carolina Highway 200 (NC 200) is a primary state highway in the U.S. state of North Carolina. The highway runs north–south from the South Carolina state line near the community of JAARS, to US 601 near Concord.
North Carolina Highway 109 (NC 109) is a north–south state highway in North Carolina. It primarily connects small towns in the central Piedmont region of the state. The 117-mile (188 km) route is a two-lane road for most of its length, but the segment between Winston-Salem and Thomasville is being upgraded to a divided 4-lane highway. The central segment of NC 109 passes through the Uwharrie Mountains and the Uwharrie National Forest.
North Carolina Highway 268 (NC 268) is a primary state highway in the U.S. state of North Carolina. It connects many communities as it traverses through the northwestern North Carolina mountains and foothills.
U.S. Route 29 is a north–south United States highway that runs for 168 miles (270 km) from the South Carolina state line, near Blacksburg, to the commonwealth of Virginia, near Danville. The route serves the North Carolina Piedmont, including the cities of Charlotte, Salisbury, High Point, and Greensboro.
North Carolina Highway 294 (NC 294) is a primary state highway in the U.S. state of North Carolina. The highway serves to connect communities along the southern banks of the Hiwassee River.
North Carolina Highway 93 (NC 93) is a primary state highway in the U.S. state of North Carolina. It runs from the Virginia state line to the community of Twin Oaks, entirely in Alleghany County.
North Carolina Highway 152 (NC 152) is a 25.5-mile-long (41.0 km) primary state highway in the U.S. state of North Carolina. It serves as the main thoroughfare in southern Rowan County.
