Nucleolar phosphoprotein p130

NOLC1
Identifiers
Aliases	NOLC1 , NOPP130, NOPP140, NS5ATP13, P130, Nucleolar phosphoprotein p130, nucleolar and coiled-body phosphoprotein 1, Srp40
External IDs	OMIM: 602394 HomoloGene: 68818 GeneCards: NOLC1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 102,152,176 bp [1] End 102,163,871 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 germinal epithelium parietal pleura endothelial cell pancreatic epithelial cell visceral pleura sperm tibia amniotic fluid n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding ATP binding RNA binding RNA polymerase I core binding protein heterodimerization activity DNA binding DNA-binding transcription factor activity transcription factor binding nuclear localization sequence binding protein domain specific binding box C/D RNA binding box H/ACA snoRNA binding box C/D snoRNP complex binding box H/ACA snoRNP complex binding Cellular component cytoplasm Cajal body nucleus nucleoplasm nucleolus fibrillar center box C/D RNP complex box H/ACA snoRNP complex Biological process rRNA processing cell cycle nucleolus organization regulation of translation neural crest formation neural crest cell development mitotic cell cycle response to osmotic stress positive regulation of cell population proliferation box H/ACA RNA metabolic process regulation of protein import into nucleus positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9221 n/a Ensembl ENSG00000166197 n/a UniProt Q14978 n/a RefSeq (mRNA) NM_001284388 NM_001284389 NM_004741 n/a RefSeq (protein) NP_001271317 NP_001271318 NP_004732 n/a Location (UCSC) Chr 10: 102.15 – 102.16 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene. ^{[3] [4] [5]}

Interactions

Nucleolar phosphoprotein p130 has been shown to interact with coilin ^[6] and CEBPB. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000166197 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pai CY, Chen HK, Sheu HL, Yeh NH (Oct 1995). "Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis". J Cell Sci. 108. ( Pt 5) (5): 1911–20. doi:10.1242/jcs.108.5.1911. PMID   7657714.
4. Chen HK, Pai CY, Huang JY, Yeh NH (Jan 2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol Cell Biol. 19 (12): 8536–46. doi:10.1128/MCB.19.12.8536. PMC   84972 . PMID   10567578.
5. "Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1".
6. Isaac, C; Yang Y; Meier U T (Jul 1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. 142 (2): 319–29. doi:10.1083/jcb.142.2.319. ISSN   0021-9525. PMC   2133063 . PMID   9679133.
7. Miau, L H; Chang C J; Shen B J; Tsai W H; Lee S C (Apr 1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. 273 (17): 10784–91. doi: 10.1074/jbc.273.17.10784 . ISSN   0021-9258. PMID   9553145.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Pai CY, Yeh NH (1996). "Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130". Biochem. Biophys. Res. Commun. 221 (3): 581–7. doi:10.1006/bbrc.1996.0639. PMID   8630004.
• Miau LH, Chang CJ, Tsai WH, Lee SC (1997). "Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor". Mol. Cell. Biol. 17 (1): 230–9. doi:10.1128/MCB.17.1.230. PMC   231747 . PMID   8972203.
• Li D, Meier UT, Dobrowolska G, Krebs EG (1997). "Specific interaction between casein kinase 2 and the nucleolar protein Nopp140". J. Biol. Chem. 272 (6): 3773–9. doi: 10.1074/jbc.272.6.3773 . PMID   9013635.
• Chen HK, Yeh NH (1997). "The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+". Biochem. Biophys. Res. Commun. 230 (2): 370–5. doi:10.1006/bbrc.1996.5966. PMID   9016786.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Miau LH, Chang CJ, Shen BJ, et al. (1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. 273 (17): 10784–91. doi: 10.1074/jbc.273.17.10784 . PMID   9553145.
• Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. 142 (2): 319–29. doi:10.1083/jcb.142.2.319. PMC   2133063 . PMID   9679133.
• Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130". Oncogene. 20 (39): 5533–7. doi: 10.1038/sj.onc.1204823 . PMID   11571651.
• Chiu CM, Tsay YG, Chang CJ, Lee SC (2002). "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene". J. Biol. Chem. 277 (42): 39102–11. doi: 10.1074/jbc.M205915200 . PMID   12167624.
• Wang C, Query CC, Meier UT (2003). "Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140". Mol. Cell. Biol. 22 (24): 8457–66. doi:10.1128/MCB.22.24.8457-8466.2002. PMC   139890 . PMID   12446766.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.