OLA1

OLA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OHF
Identifiers
Aliases	OLA1 , DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1
External IDs	OMIM: 611175 MGI: 1914309 HomoloGene: 5361 GeneCards: OLA1
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q31.1 Start 174,072,447 bp [1] End 174,248,599 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C3 Start 72,923,145 bp [2] End 73,049,268 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ganglionic eminence pons Brodmann area 23 lactiferous duct parotid gland entorhinal cortex prefrontal cortex vulva biceps brachii Top expressed in Paneth cell cumulus cell condyle ureter medial ganglionic eminence primitive streak barrel cortex hair follicle fossa motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding hydrolase activity metal ion binding ATP binding ATPase activity cadherin binding ribosome binding ribosomal large subunit binding Cellular component centrosome nucleolus extracellular exosome membrane nucleus extracellular region cytoplasm cytosol platelet alpha granule lumen Biological process ATP metabolic process platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29789 67059 Ensembl ENSG00000138430 ENSMUSG00000027108 UniProt Q9NTK5 Q9CZ30 RefSeq (mRNA) NM_013341 NM_001011708 NM_001328688 NM_025942 NM_030091 RefSeq (protein) NP_001011708 NP_001315617 NP_037473 NP_080218 NP_084367 Location (UCSC) Chr 2: 174.07 – 174.25 Mb Chr 2: 72.92 – 73.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene. ^{[5] [6]} Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine triphosphate (ATP) with higher affinity than guanosine triphosphate (GTP). ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000138430 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027108 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi: 10.1074/jbc.M700541200 . PMID   17430889.
6. "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9NTK5 (Obg-like ATPase 1) at the PDBe-KB .