OR10A2

OR10A2
Identifiers
Aliases	OR10A2 , OR10A2P, OR11-82, OR11-86, OST363, olfactory receptor family 10 subfamily A member 2
External IDs	MGI: 3030548 HomoloGene: 72055 GeneCards: OR10A2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 6,863,057 bp [1] End 6,874,717 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 106,670,188 bp [2] End 106,677,009 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in reproductive system reproductive organ gonad male reproductive system testicle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 341276 259035 Ensembl ENSG00000170790 ENSMUSG00000049674 UniProt Q9H208 Q7TRN0 RefSeq (mRNA) NM_001004460 NM_147033 RefSeq (protein) NP_001004460 NP_667244 Location (UCSC) Chr 11: 6.86 – 6.87 Mb Chr 7: 106.67 – 106.68 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor family 10 subfamily A member 2 is a protein that in humans is encoded by the OR10A2 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].

Genetic differences

OR10A2 (as well as OR6A2 which is located near it on chromosome 11) has been proposed as a candidate gene responsible for the genetic portion of the variation in cilantro preference. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000170790 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049674 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Olfactory receptor family 10 subfamily A member 2" . Retrieved 2020-04-19.
6. Eriksson N, Wu S, Do CB, Kiefer AK, Tung JY, Mountain JL, Hinds DA, Francke U (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv: 1209.2096 . doi: 10.1186/2044-7248-1-22 . S2CID   199627.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.