ORAI2

ORAI2
Identifiers
Aliases	ORAI2 , C7orf19, CBCIP2, MEM142B, TMEM142B, ORAI calcium release-activated calcium modulator 2
External IDs	OMIM: 610929; MGI: 2443195; HomoloGene: 32799; GeneCards: ORAI2; OMA:ORAI2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 102,433,106 bp [1] End 102,456,825 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 136,176,313 bp [2] End 136,199,567 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla ventral tegmental area pylorus superior vestibular nucleus nipple inferior ganglion of vagus nerve superior surface of tongue trigeminal ganglion pericardium subthalamic nucleus Top expressed in granulocyte dentate gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper primary visual cortex superior frontal gyrus piriform cortex thymus olfactory tubercle cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function store-operated calcium channel activity protein binding Cellular component growth cone integral component of membrane membrane Biological process store-operated calcium entry calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80228 269717 Ensembl ENSG00000160991 ENSMUSG00000039747 UniProt Q96SN7 Q8BH10 RefSeq (mRNA) NM_032831 NM_001126340 NM_001271818 NM_001271819 NM_178751 RefSeq (protein) NP_001119812 NP_001258747 NP_001258748 NP_116220 NP_848866 Location (UCSC) Chr 7: 102.43 – 102.46 Mb Chr 5: 136.18 – 136.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000160991 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039747 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID   16582901. S2CID   1605392.
6. "Entrez Gene: TMEM142B transmembrane protein 142B".

Further reading

• DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels". J. Biol. Chem. 282 (24): 17548–56. doi: 10.1074/jbc.M611374200 . PMID   17452328.
• Mercer JC, Dehaven WI, Smyth JT, et al. (2006). "Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1". J. Biol. Chem. 281 (34): 24979–90. doi: 10.1074/jbc.M604589200 . PMC   1633822 . PMID   16807233.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.