ORM1

ORM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KQ0
Identifiers
Aliases	ORM1 , AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs	OMIM: 138600; MGI: 97445; HomoloGene: 128040; GeneCards: ORM1; OMA:ORM1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q32 Start 114,323,098 bp [1] End 114,326,479 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 B3|4 33.96 cM Start 63,274,399 bp [2] End 63,277,748 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle bone marrow bone marrow cells blood trabecular bone granulocyte right lung right adrenal gland upper lobe of left lung Top expressed in seminal vesicula granulocyte embryo adrenal gland white adipose tissue liver brown adipose tissue tunica adventitia of aorta left lobe of liver neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component blood microparticle extracellular exosome platelet alpha granule lumen extracellular space specific granule lumen tertiary granule lumen extracellular matrix extracellular region collagen-containing extracellular matrix Biological process negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production regulation of immune system process inflammatory response acute-phase response platelet degranulation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5004 18407 Ensembl ENSG00000229314 ENSMUSG00000028359 UniProt P02763 Q63805 RefSeq (mRNA) NM_000607 NM_013623 NM_001379520 NM_001379521 RefSeq (protein) NP_000598 n/a Location (UCSC) Chr 9: 114.32 – 114.33 Mb Chr 4: 63.27 – 63.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. ^[5]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. ^[5]

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1. ^[6]

See also

• Orosomucoid

References

1. GRCh38: Ensembl release 89: ENSG00000229314 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028359 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ORM1 orosomucoid 1".
6. Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. 276 (38). United States: 35305–11. doi: 10.1074/jbc.M104028200 . ISSN   0021-9258. PMID   11418606.

Further reading

• Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein". Biochem. J. 283 (1): 105–12. doi:10.1042/bj2830105. PMC   1131000 . PMID   1567356.
• Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC   341288 . PMID   2409529.
• Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate". Prostate. 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID   2479939. S2CID   84445745.
• Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. PMID   2541064. S2CID   42021177.
• Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein". EMBO J. 6 (8): 2289–96. doi:10.1002/j.1460-2075.1987.tb02503.x. PMC   553631 . PMID   2822385.
• Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene". Gene. 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID   2970990.
• Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice". Genes Dev. 2 (2): 259–66. doi: 10.1101/gad.2.2.259 . PMID   3360326.
• Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID   3463531. S2CID   34725840.
• Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA". Gene. 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID   3770479.
• Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID   3795040.
• Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment". Biochemistry. 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID   4561179.
• Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein". Biochemistry. 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID   4603214.
• Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins". Biochemistry. 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID   4711474.
• Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID   6809283. S2CID   13305518.
• Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans". Glycoconj. J. 12 (1): 7–16. doi: 10.1007/BF00731863 . PMID   7795416. S2CID   23508679.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID   8076819.
• Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis" (PDF). Inflammation. 17 (1): 33–45. doi:10.1007/BF00916390. hdl: 2027.42/44509 . PMID   8432561. S2CID   6012698.
• Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID   9050929. S2CID   21298011.
• Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum". Pharmacology. 54 (5): 271–5. doi:10.1159/000139495. PMID   9380773.
• Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID   11027547.