OSBPL1A

OSBPL1A
Identifiers
Aliases	OSBPL1A , ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDs	OMIM: 606730; MGI: 1927551; HomoloGene: 84746; GeneCards: OSBPL1A; OMA:OSBPL1A - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q11.2 Start 24,162,045 bp [1] End 24,397,880 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 A1 Start 12,888,371 bp [2] End 13,074,898 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum internal globus pallidus inferior ganglion of vagus nerve postcentral gyrus external globus pallidus subthalamic nucleus pons pars reticulata lateral nuclear group of thalamus occipital lobe Top expressed in prefrontal cortex deep cerebellar nuclei barrel cortex medial geniculate nucleus primary motor cortex medial dorsal nucleus pontine nuclei lateral geniculate nucleus medial vestibular nucleus olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding protein binding phospholipid binding lipid binding sterol transporter activity sterol binding Cellular component endosome late endosome intracellular anatomical structure extracellular exosome cytosol membrane intracellular membrane-bounded organelle Biological process lipid transport cholesterol metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class II vesicle-mediated transport bile acid biosynthetic process sterol transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114876 64291 Ensembl ENSG00000141447 ENSMUSG00000044252 UniProt Q9BXW6 Q91XL9 RefSeq (mRNA) NM_001242508 NM_018030 NM_080597 NM_133268 NM_001252489 NM_001252490 NM_001252491 NM_001252492 NM_001252493 NM_020573 NM_207530 RefSeq (protein) NP_001229437 NP_060500 NP_542164 NP_001239418 NP_001239419 NP_001239420 NP_001239421 NP_001239422 NP_997413 Location (UCSC) Chr 18: 24.16 – 24.4 Mb Chr 18: 12.89 – 13.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene. ^{[5] [6] [7]}

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141447 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044252 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi: 10.1074/jbc.M101204200 . PMID   11279184.
6. Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. doi: 10.1016/S0022-2275(20)32095-2 . PMID   10588946.
7. "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

Further reading

• Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi: 10.1016/S0022-2275(20)31570-4 . PMID   11483621.
• Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID   11735225.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct". Mol. Biol. Cell. 14 (3): 903–15. doi:10.1091/mbc.E02-08-0459. PMC   151568 . PMID   12631712.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments". Mol. Biol. Cell. 16 (12): 5480–92. doi:10.1091/mbc.E05-03-0189. PMC   1289395 . PMID   16176980.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.