OSBPL1A

OSBPL1A
Identifiers
Aliases	OSBPL1A , ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDs	OMIM: 606730 MGI: 1927551 HomoloGene: 84746 GeneCards: OSBPL1A
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,397,880 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	13,074,898 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; external globus pallidus; ; subthalamic nucleus; ; pons; ; occipital lobe; ; entorhinal cortex; ; prefrontal cortex;
	Top expressed in
	prefrontal cortex; ; barrel cortex; ; medial geniculate nucleus; ; primary motor cortex; ; medial dorsal nucleus; ; pontine nuclei; ; lateral geniculate nucleus; ; medial vestibular nucleus; ; olfactory epithelium; ; globus pallidus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding ; protein binding ; phospholipid binding ; lipid binding ; sterol transporter activity ; sterol binding ;
Cellular component	endosome ; late endosome ; intracellular anatomical structure ; extracellular exosome ; cytosol ; membrane ; intracellular membrane-bounded organelle ;
Biological process	lipid transport ; cholesterol metabolic process ; antigen processing and presentation of exogenous peptide antigen via MHC class II ; vesicle-mediated transport ; bile acid biosynthetic process ; sterol transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	114876
	64291
	ENSG00000141447
	ENSMUSG00000044252
	Q9BXW6
	Q91XL9
	NM_001242508 ; NM_018030 ; NM_080597 ; NM_133268
NM_001252489 ; NM_001252490 ; NM_001252491 ; NM_001252492 ; NM_001252493 ;
	NM_020573 ; NM_207530
	NP_001229437 ; NP_060500 ; NP_542164
NP_001239418 ; NP_001239419 ; NP_001239420 ; NP_001239421 ; NP_001239422 ;
	NP_997413
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.^[5]^[6]^[7]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.^[7]

Related Research Articles

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Non-specific lipid-transfer protein also known as steroy carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene.

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene. Its gene product, as well as the gene itself, is commonly known as TIP47.

ATP-binding cassette sub-family G member 8 is a protein that in humans is encoded by the ABCG8 gene.

<span class="mw-page-title-main">Oxysterol-binding protein</span>

The oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of lipid transfer proteins (LTPs). Concretely, they constitute a family of sterol and phosphoinositide binding and transfer proteins in eukaryotes that are conserved from yeast to humans. They are lipid-binding proteins implicated in many cellular processes related with oxysterol, including signaling, vesicular trafficking, lipid metabolism, and nonvesicular sterol transport.

Clathrin interactor 1 (CLINT1), also known as EPSIN4, is a protein which in humans is encoded by the CLINT1 gene.

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.

Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. IFITM1 has also recently been designated CD225. This protein has several additional names: fragilis, IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.

VAMP-Associated Protein A is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes.

25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Oxysterol-binding protein 1 is a protein that in humans is encoded by the OSBP gene.

Insulin induced gene 2, also known as INSIG2, is a protein which in humans is encoded by the INSIG2 gene.

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

<span class="mw-page-title-main">OSBPL2</span> Protein-coding gene in the species Homo sapiens

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.

Oxysterol binding protein-like 9 is a protein that in humans is encoded by the OSBPL9 gene.

StAR-related lipid transfer protein 4 (STARD4) is a soluble protein involved in cholesterol transport. It can transfer up to 7 sterol molecules per minute between artificial membranes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141447 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044252 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi: 10.1074/jbc.M101204200 . PMID 11279184.
↑ Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. doi: 10.1016/S0022-2275(20)32095-2 . PMID 10588946.
1 2 "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi: 10.1016/S0022-2275(20)31570-4 . PMID 11483621.
Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct". Mol. Biol. Cell. 14 (3): 903–15. doi:10.1091/mbc.E02-08-0459. PMC 151568 . PMID 12631712.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments". Mol. Biol. Cell. 16 (12): 5480–92. doi:10.1091/mbc.E05-03-0189. PMC 1289395 . PMID 16176980.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141447 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044252 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11279184-5] Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi: 10.1074/jbc.M101204200 . PMID 11279184.

[pmid10588946-6] Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. doi: 10.1016/S0022-2275(20)32095-2 . PMID 10588946.

[entrez-7] 1 2 "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

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OSBPL1A

Related Research Articles

References

Further reading