OSTF1

OSTF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X2K, 1ZLM, 3EHQ, 3EHR
Identifiers
Aliases	OSTF1 , OSF, SH3P2, bA235O14.1, osteoclast stimulating factor 1
External IDs	OMIM: 610180 MGI: 700012 HomoloGene: 8227 GeneCards: OSTF1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	75,147,265 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	18,609,187 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; right lung; ; skin of abdomen; ; spleen; ; upper lobe of left lung; ; gallbladder; ; rectum; ; lymph node; ; minor salivary gland;
	Top expressed in
	spleen; ; lip; ; corneal stroma; ; sciatic nerve; ; esophagus; ; right lung lobe; ; left lung lobe; ; cervix; ; calvaria; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding ; protein binding ;
Cellular component	cytoplasm ; intracellular anatomical structure ; secretory granule lumen ; ficolin-1-rich granule lumen ; extracellular region ;
Biological process	ossification ; signal transduction ; neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	26578
	20409
	ENSG00000134996
	ENSMUSG00000024725
	Q92882
	Q62422
	NM_012383
	NM_017375
	NP_036515
	NP_059071
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134996 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024725 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216. S2CID 34911988.
↑ "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sparks AB, Hoffman NG, McConnell SJ, et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982. S2CID 11166026.
Schaub R, Dupont B, Roodman GD, et al. (2000). "Assignment of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 87–8. doi:10.1159/000015492. PMID 10773673. S2CID 41580372.
Kurihara N, Menaa C, Maeda H, et al. (2001). "Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation". J. Biol. Chem. 276 (44): 41035–9. doi: 10.1074/jbc.M100233200 . PMID 11551898.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Szymkiewicz I, Destaing O, Jurdic P, Dikic I (2004). "SH3P2 in complex with Cbl and Src". FEBS Lett. 565 (1–3): 33–8. doi: 10.1016/j.febslet.2004.03.100 . PMID 15135048. S2CID 22127534.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Li M, Meng Z, Xu Y, et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor". Acta Crystallographica Section F. 61 (Pt 1): 128–30. doi:10.1107/S1744309104031653. PMC 1952375 . PMID 16508112.
Chen L, Wang Y, Wells D, et al. (2006). "Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution". Acta Crystallographica Section F. 62 (Pt 9): 844–8. doi:10.1107/S1744309106030004. PMC 2242886 . PMID 16946461.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134996 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024725 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10092216-5] Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216. S2CID 34911988.

[entrez-6] "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

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OSTF1

Related Research Articles

References

Further reading