OSTF1

OSTF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X2K, 1ZLM, 3EHQ, 3EHR
Identifiers
Aliases	OSTF1 , OSF, SH3P2, bA235O14.1, osteoclast stimulating factor 1
External IDs	OMIM: 610180; MGI: 700012; HomoloGene: 8227; GeneCards: OSTF1; OMA:OSTF1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q21.13 Start 75,088,514 bp [1] End 75,147,265 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 B|19 13.17 cM Start 18,493,501 bp [2] End 18,609,187 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood right lung skin of abdomen spleen upper lobe of left lung skin of leg gallbladder rectum Top expressed in granulocyte stroma of bone marrow decidua right kidney gastrula spleen Ileal epithelium lip corneal stroma sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding Cellular component cytoplasm intracellular anatomical structure secretory granule lumen ficolin-1-rich granule lumen extracellular region Biological process ossification signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26578 20409 Ensembl ENSG00000134996 ENSMUSG00000024725 UniProt Q92882 Q62422 RefSeq (mRNA) NM_012383 NM_017375 RefSeq (protein) NP_036515 NP_059071 Location (UCSC) Chr 9: 75.09 – 75.15 Mb Chr 19: 18.49 – 18.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000134996 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024725 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID   10092216. S2CID   34911988.
6. "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Sparks AB, Hoffman NG, McConnell SJ, et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID   9630982. S2CID   11166026.
• Schaub R, Dupont B, Roodman GD, et al. (2000). "Assignment of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 87–8. doi:10.1159/000015492. PMID   10773673. S2CID   41580372.
• Kurihara N, Menaa C, Maeda H, et al. (2001). "Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation". J. Biol. Chem. 276 (44): 41035–9. doi: 10.1074/jbc.M100233200 . PMID   11551898.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Szymkiewicz I, Destaing O, Jurdic P, Dikic I (2004). "SH3P2 in complex with Cbl and Src". FEBS Lett. 565 (1–3): 33–8. doi: 10.1016/j.febslet.2004.03.100 . PMID   15135048. S2CID   22127534.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Li M, Meng Z, Xu Y, et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor". Acta Crystallographica Section F. 61 (Pt 1): 128–30. doi:10.1107/S1744309104031653. PMC   1952375 . PMID   16508112.
• Chen L, Wang Y, Wells D, et al. (2006). "Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution". Acta Crystallographica Section F. 62 (Pt 9): 844–8. doi:10.1107/S1744309106030004. PMC   2242886 . PMID   16946461.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.