OTUB2

OTUB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TFF, 4FJV
Identifiers
Aliases	OTUB2 , C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
External IDs	OMIM: 608338 MGI: 1915399 HomoloGene: 57056 GeneCards: OTUB2
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.12 Start 94,026,340 bp [1] End 94,048,930 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 E Start 103,354,941 bp [2] End 103,372,609 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen ganglionic eminence placenta islet of Langerhans stromal cell of endometrium prefrontal cortex superior frontal gyrus rectum dorsolateral prefrontal cortex Brodmann area 9 Top expressed in seminiferous tubule spermatid esophagus lip Region I of hippocampus proper lacrimal gland secondary oocyte calvaria hippocampus proper substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity NEDD8-specific protease activity ubiquitin binding protein binding hydrolase activity Cellular component nucleus Biological process protein deubiquitination protein K63-linked deubiquitination protein K48-linked deubiquitination proteolysis protein K11-linked deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 78990 68149 Ensembl ENSG00000089723 ENSG00000277276 ENSMUSG00000021203 UniProt Q96DC9 Q9CQX0 RefSeq (mRNA) NM_023112 NM_001177841 NM_026580 RefSeq (protein) NP_075601 NP_001171312 NP_080856 Location (UCSC) Chr 14: 94.03 – 94.05 Mb Chr 12: 103.35 – 103.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene. ^{[5] [6]}

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond. ^[6]

References

1. ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021203 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC   1319179 . PMID   12704427.
6. "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2". EMBO Rep. 5 (8): 783–8. doi:10.1038/sj.embor.7400201. PMC   1299112 . PMID   15258613.
• Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID   15014966. S2CID   8594824.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi: 10.1038/nature01348 . PMID   12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.