OTUD4

OTUD4
Identifiers
Aliases	OTUD4 , DUBA6, HIN1, HSHIN1, OTU deubiquitinase 4
External IDs	OMIM: 611744 MGI: 1098801 HomoloGene: 35370 GeneCards: OTUD4
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.21 Start 145,110,838 bp [1] End 145,180,589 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 C1|8 37.74 cM Start 80,366,247 bp [2] End 80,404,353 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle frontal gyrus Brodmann area 10 frontal pole thoracic diaphragm body of tongue biceps brachii cerebellar vermis external globus pallidus vena cava right ventricle Top expressed in otic placode saccule cumulus cell secondary oocyte atrioventricular valve atrium primitive streak blood pineal gland abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity protein binding hydrolase activity RNA binding molecular adaptor activity Lys63-specific deubiquitinase activity Cellular component cellular component nucleus cytoplasm Biological process protein K48-linked deubiquitination proteolysis immune system process negative regulation of toll-like receptor signaling pathway innate immune response protein K63-linked deubiquitination positive regulation of DNA demethylation regulation of protein K48-linked deubiquitination negative regulation of interleukin-1-mediated signaling pathway protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54726 73945 Ensembl ENSG00000164164 ENSMUSG00000036990 UniProt Q01804 B2RRE7 RefSeq (mRNA) NM_001102653 NM_017493 NM_199324 NM_001366057 NM_001366058 NM_001081164 NM_001256033 RefSeq (protein) NP_001096123 NP_059963 NP_001352986 NP_001352987 NP_001074633 NP_001242962 Location (UCSC) Chr 4: 145.11 – 145.18 Mb Chr 8: 80.37 – 80.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene. ^{[5] [6] [7]}

Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164164 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036990 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Raineri I, Senn HP (Feb 1993). "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts". Nucleic Acids Res. 20 (23): 6261–6. doi:10.1093/nar/20.23.6261. PMC   334514 . PMID   1475186.
6. Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K (May 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024–7. PMID   12727813.
7. "Entrez Gene: OTUD4 OTU domain containing 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID   10470851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.