OXA1L

OXA1L
Identifiers
Aliases	OXA1L , OXA1, mitochondrial inner membrane protein, OXA1L mitochondrial inner membrane protein
External IDs	OMIM: 601066 MGI: 1916339 HomoloGene: 31281 GeneCards: OXA1L
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 22,766,522 bp [1] End 22,773,042 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C2 Start 54,598,291 bp [2] End 54,607,130 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas thoracic diaphragm gastrocnemius muscle triceps brachii muscle left ventricle body of stomach rectum Left adrenal gland gastric mucosa right lobe of liver Top expressed in yolk sac lip myocardium of ventricle skeletal muscle tissue superior frontal gyrus submandibular gland proximal tubule external carotid artery adrenal gland thymus More reference expression data BioGPS n/a
Gene ontology Molecular function mitochondrial ribosome binding protein binding protein homodimerization activity membrane insertase activity Cellular component integral component of membrane mitochondrial inner membrane integral component of mitochondrial membrane mitochondrial membrane mitochondrion membrane mitochondrial respirasome protein-containing complex mitochondrial matrix integral component of mitochondrial inner membrane Biological process negative regulation of ATP-dependent activity aerobic respiration mitochondrial proton-transporting ATP synthase complex assembly protein tetramerization negative regulation of oxidoreductase activity mitochondrial respiratory chain complex I assembly protein-containing complex assembly protein transport mitochondrial translational elongation mitochondrial translational termination protein insertion into mitochondrial inner membrane from matrix mitochondrial cytochrome c oxidase assembly protein insertion into membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5018 69089 Ensembl ENSG00000155463 ENSMUSG00000000959 UniProt Q15070 Q8BGA9 RefSeq (mRNA) NM_005015 NM_026936 RefSeq (protein) NP_005006 NP_081212 Location (UCSC) Chr 14: 22.77 – 22.77 Mb Chr 14: 54.6 – 54.61 Mb PubMed search [3] [4]
Wikidata
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Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2. ^[5] The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria. ^{[6] [7]}

Reference

1. GRCh38: Ensembl release 89: ENSG00000155463 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000959 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Molina-Gomes D, Bonnefoy N, Nguyen VC, Viegas-Péquignot E, Rötig A, Dujardin G (1995). "The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome". Genomics. 30 (2): 396–8. PMID   8586451.
6. Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL (2010). "Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes". The Journal of Biological Chemistry. 285 (36): 28353–62. doi: 10.1074/jbc.M110.148262 . PMC   2934699 . PMID   20601428.
7. Haque ME, Spremulli LL, Fecko CJ (2010). "Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L". The Journal of Biological Chemistry. 285 (45): 34991–8. doi: 10.1074/jbc.M110.163808 . PMC   2966113 . PMID   20739282.