Olfactomedin-like 3

OLFML3
Identifiers
Aliases	OLFML3 , HNOEL-iso, OLF44, olfactomedin like 3
External IDs	OMIM: 610088 MGI: 1914877 HomoloGene: 10613 GeneCards: OLFML3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 113,979,391 bp [1] End 114,035,572 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 103,629,538 bp [2] End 103,645,317 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder left uterine tube placenta Achilles tendon canal of the cervix smooth muscle tissue myometrium stromal cell of endometrium vagina gastric mucosa Top expressed in lip Meckel's cartilage mirror yolk sac neural tube Hindgut stomach duodenum esophagus uterus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 56944 99543 Ensembl ENSG00000116774 ENSMUSG00000027848 UniProt Q9NRN5 Q8BK62 RefSeq (mRNA) NM_020190 NM_001286352 NM_001286353 NM_133859 RefSeq (protein) NP_001273281 NP_001273282 NP_064575 NP_064575.1 NP_598620 Location (UCSC) Chr 1: 113.98 – 114.04 Mb Chr 3: 103.63 – 103.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactomedin-like protein 3 is a protein that in humans is encoded by the OLFML3 gene. ^[5] It has been shown to act as a proangiongenic factor in the tumor microenvironment, being released by endothelial cells and pericytes. ^[6]

This gene has also been associated with pectinate ligament dysplasia and glaucoma in Border Collies. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116774 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027848 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OLFML3 olfactomedin-like 3".
6. Miljkovic-Licina M, Hammel P, Garrido-Urbani S, Lee BP, Meguenani M, Chaabane C, et al. (December 2012). "Targeting olfactomedin-like 3 inhibits tumor growth by impairing angiogenesis and pericyte coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi: 10.1158/1535-7163.MCT-12-0245 . PMID   23002094.
7. Oliver JA, Wright H, Massidda PA, Burmeister LM, Mellersh CS (January 2020). "A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom". Veterinary Ophthalmology. 23 (1): 25–36. doi:10.1111/vop.12680. PMID   31141290. S2CID   169036374.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Zeng LC, Liu F, Zhang X, Zhu ZD, Wang ZQ, Han ZG, Ma WJ (July 2004). "hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis". FEBS Letters. 571 (1–3): 74–80. doi: 10.1016/j.febslet.2004.06.059 . PMID   15280020.
• Fautsch MP, Vrabel AM, Johnson DH (June 2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Experimental Eye Research. 82 (6): 1046–1052. doi:10.1016/j.exer.2005.09.016. PMID   16289162.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi: 10.1093/dnares/12.2.117 . PMID   16303743.