PAPLN

PAPLN
Identifiers
Aliases	PAPLN , papilin, proteoglycan like sulfated glycoprotein, PPN
External IDs	OMIM: 617785; MGI: 2386139; HomoloGene: 71541; GeneCards: PAPLN; OMA:PAPLN - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.2 Start 73,237,497 bp [1] End 73,274,640 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 D1 Start 83,810,408 bp [2] End 83,839,156 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve tendon of biceps brachii decidua trigeminal ganglion spinal ganglia gastric mucosa sural nerve skin of arm left uterine tube lymph node Top expressed in molar lip spermatocyte esophagus superior frontal gyrus yolk sac neural layer of retina muscle of thigh primary visual cortex spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity peptidase activity serine-type endopeptidase inhibitor activity Cellular component extracellular region Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89932 170721 Ensembl ENSG00000100767 ENSMUSG00000021223 UniProt O95428 Q9EPX2 RefSeq (mRNA) NM_173462 NM_001365906 NM_001365907 NM_001205343 NM_130887 RefSeq (protein) NP_775733 NP_001352835 NP_001352836 NP_001192272 NP_570957 Location (UCSC) Chr 14: 73.24 – 73.27 Mb Chr 12: 83.81 – 83.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Papilin is a protein that in humans is encoded by the PAPLN gene. ^{[5] [6] [7]} Papilin is an extracellular matrix glycoprotein.

References

1. GRCh38: Ensembl release 89: ENSG00000100767 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021223 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: papilin".
6. Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov AA, Kusche-Gullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ, Fessler JH (December 2000). "Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases". Development. 127 (24): 5475–85. doi:10.1242/dev.127.24.5475. PMID   11076767.
7. Apte SS (November 2009). "A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms". J. Biol. Chem. 284 (46): 31493–7. doi: 10.1074/jbc.R109.052340 . PMC   2797218 . PMID   19734141.

Further reading

• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Laje G, Allen AS, Akula N, et al. (2009). "Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients". Pharmacogenet. Genomics. 19 (9): 666–74. doi:10.1097/FPC.0b013e32832e4bcd. PMC   2819190 . PMID   19724244.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.