PARD3B

PARD3B
Identifiers
Aliases	PARD3B , ALS2CR19, PAR3B, PAR3L, PAR3LC, PAR3beta, Par3Lb, par-3 family cell polarity regulator beta
External IDs	MGI: 1919301; HomoloGene: 35389; GeneCards: PARD3B; OMA:PARD3B - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q33.3 Start 204,545,475 bp [1] End 205,620,162 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C2 Start 61,677,983 bp [2] End 62,681,443 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone Achilles tendon epithelium of colon saphenous vein tibial arteries mucosa of ileum testicle gonad skin of hip Top expressed in Rostral migratory stream crypt of lieberkuhn of small intestine internal carotid artery external carotid artery sciatic nerve lumbar spinal ganglion renal corpuscle ciliary body iris intestinal villus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol binding Cellular component membrane endomembrane system bicellular tight junction cell junction nucleoplasm nuclear body protein-containing complex cytoplasm adherens junction cell cortex apical plasma membrane apical junction complex Biological process cell division cell cycle microtubule cytoskeleton organization cell adhesion protein localization establishment of cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment of centrosome localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117583 72823 Ensembl ENSG00000116117 ENSMUSG00000052062 UniProt Q8TEW8 Q9CSB4 RefSeq (mRNA) NM_001302769 NM_057177 NM_152526 NM_205863 NM_001081050 RefSeq (protein) NP_001289698 NP_476518 NP_689739 NP_995585 NP_001074519 Location (UCSC) Chr 2: 204.55 – 205.62 Mb Chr 1: 61.68 – 62.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Partitioning defective 3 homolog B is a protein that in humans is encoded by the PARD3B gene. ^{[5] [6] [7]}

Interactions

PARD3B has been shown to interact with Mothers against decapentaplegic homolog 3. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000116117 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052062 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID   11586298. S2CID   52828189.
6. Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID   12459187.
7. "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".
8. Warner DR, Pisano M Michele, Roberts Emily A, Greene Robert M (Mar 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3). Netherlands: 167–73. doi: 10.1016/S0014-5793(03)00155-8 . ISSN   0014-5793. PMID   12650946. S2CID   7429554.

Further reading

• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID   16458856.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2005). "Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein". Biochem. Biophys. Res. Commun. 329 (1): 211–8. doi:10.1016/j.bbrc.2005.01.115. PMID   15721295.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi: 10.1016/S0014-5793(03)00155-8 . PMID   12650946. S2CID   7429554.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID   12234671.