PARP12

PARP12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PQF
Identifiers
Aliases	PARP12 , ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1, poly(ADP-ribose) polymerase family member 12
External IDs	OMIM: 612481 MGI: 2143990 HomoloGene: 11236 GeneCards: PARP12
Gene location (Human)
Chr.	Chromosome 7 (human)
End	140,062,951 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	39,095,283 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right lung; ; upper lobe of left lung; ; monocyte; ; spleen; ; rectum; ; tibial nerve; ; pancreatic ductal cell; ; right uterine tube; ; lymph node;
	Top expressed in
	secondary oocyte; ; intestinal villus; ; pineal gland; ; mucous cell of stomach; ; left colon; ; jejunum; ; ileum; ; duodenum; ; parotid gland; ; right lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD+ ADP-ribosyltransferase activity ; metal ion binding ; transferase activity ; RNA binding ; protein ADP-ribosylase activity ;
Cellular component	nucleus ;
Biological process	protein auto-ADP-ribosylation ; protein mono-ADP-ribosylation ;
	Sources:Amigo / QuickGO
Orthologs
	64761
	243771
	ENSG00000059378
	ENSMUSG00000038507
	Q9H0J9
	Q8BZ20
	NM_022750
	NM_172893
	NP_073587
	NP_766481
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Poly [ADP-ribose] polymerase 12 is an enzyme that in humans is encoded by the PARP12 gene.^[5]^[6]^[7]

Related Research Articles

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD⁺ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. It is the most abundant of the PARP family of enzymes, accounting for 90% of the NAD+ used by the family. PARP1 is mostly present in cell nucleus, but cytosolic fraction of this protein was also reported.

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.

Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. It is one of the PARP family of enzymes.

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.

Poly [ADP-ribose] polymerase 8 is an enzyme that in humans is encoded by the PARP8 gene.

Allograft inflammatory factor 1-like is a protein that is encoded by the AIF1L gene in humans.

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.

RNA-binding protein 33 is a protein that in humans is encoded by the RBM33 gene.

TCDD-inducible poly [ADP-ribose] polymerase is an enzyme that in humans is encoded by the TIPARP gene.

Glyoxalase domain-containing protein 4 is an enzyme that in humans is encoded by the GLOD4 gene.

GET4 is a protein that in humans is encoded by the GET4 gene.

DnaJ homolog subfamily C member 11 is a protein that in humans is encoded by the DNAJC11 gene.

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000059378 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038507 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
↑ Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID 12851707.
↑ "Entrez Gene: PARP12 poly (ADP-ribose) polymerase family, member 12".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000059378 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038507 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.

[pmid12851707-6] Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID 12851707.

[entrez-7] "Entrez Gene: PARP12 poly (ADP-ribose) polymerase family, member 12".

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PARP12

Related Research Articles

References

Further reading