PCDH12 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | PCDH12 , VE-cadherin-2, VECAD2, protocadherin 12, DMJDS1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605622 MGI: 1855700 HomoloGene: 9574 GeneCards: PCDH12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene. [5] [6] [7]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth. [7]
Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.
Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.
Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.
Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.
Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.
Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.
Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
Protocadherin alpha-2 is a protein that in humans is encoded by the PCDHA2 gene.
Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.
Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.
Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.
Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.
Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.
Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.
Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene.
Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.
Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.
Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene.
Protocadherin-20 is a protein that in humans is encoded by the PCDH20 gene.