PCDH20

PCDH20
Identifiers
Aliases	PCDH20 , PCDH13, protocadherin 20
External IDs	OMIM: 614449; MGI: 2443376; HomoloGene: 11277; GeneCards: PCDH20; OMA:PCDH20 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q21.2 Start 61,409,685 bp [1] End 61,415,522 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E1 Start 88,702,179 bp [2] End 88,708,832 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus testicle prefrontal cortex hippocampus proper popliteal artery tibial arteries Achilles tendon Brodmann area 9 anterior cingulate cortex Descending thoracic aorta Top expressed in utricle vestibular sensory epithelium vestibular membrane of cochlear duct dentate gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper lumbar subsegment of spinal cord endolymphatic duct Region I of hippocampus proper mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding RNA binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64881 219257 Ensembl ENSG00000280165 ENSMUSG00000050505 UniProt Q8N6Y1 Q8BIZ0 RefSeq (mRNA) NM_022843 NM_178685 RefSeq (protein) NP_073754 NP_848800 Location (UCSC) Chr 13: 61.41 – 61.42 Mb Chr 14: 88.7 – 88.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-20 is a protein that in humans is encoded by the PCDH20 gene. ^[5]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000280165 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050505 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PCDH20 protocadherin 20".

Further reading

• Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID   11082270.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID   10835267.
• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi: 10.1101/gad.14.10.1169 . PMID   10817752. S2CID   44844497.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039. S2CID   21903526.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID   8012384. S2CID   12847618.