PCDH7

PCDH7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2YST
Identifiers
Aliases	PCDH7 , BH-Pcdh, BHPCDH, PPP1R120, protocadherin 7
External IDs	OMIM: 602988 MGI: 1860487 HomoloGene: 36101 GeneCards: PCDH7
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p15.1 Start 30,720,369 bp [1] End 31,146,805 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C1 Start 57,875,309 bp [2] End 58,290,572 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 urethra saphenous vein corpus epididymis seminal vesicula pons entorhinal cortex postcentral gyrus Top expressed in ascending aorta arcuate nucleus ventromedial nucleus subiculum median eminence paraventricular nucleus of hypothalamus lateral geniculate nucleus aortic valve medial geniculate nucleus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane platelet alpha granule membrane Biological process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5099 54216 Ensembl ENSG00000169851 ENSMUSG00000029108 UniProt O60245 n/a RefSeq (mRNA) NM_001173523 NM_002589 NM_032456 NM_032457 NM_001122758 NM_018764 NM_001310606 NM_001310608 RefSeq (protein) NP_001166994 NP_002580 NP_115832 NP_115833 n/a Location (UCSC) Chr 4: 30.72 – 31.15 Mb Chr 5: 57.88 – 58.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene. ^{[5] [6]}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell–cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000169851 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029108 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics. 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID   9615233.
6. "Entrez Gene: PCDH7 protocadherin 7".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi: 10.1101/gad.14.10.1169 . PMID   10817752. S2CID   44844497.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID   10835267.
• Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain". FEBS Lett. 460 (1): 93–8. doi: 10.1016/S0014-5793(99)01309-5 . PMID   10571067. S2CID   24377126.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.