PCDHA9

Last updated
PCDHA9
Identifiers
Aliases PCDHA9 , PCDH-ALPHA9, protocadherin alpha 9
External IDs OMIM: 606315 MGI: 2681879 HomoloGene: 129614 GeneCards: PCDHA9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031857
NM_014005

NM_201243

RefSeq (protein)

NP_054724
NP_114063

NP_957695

Location (UCSC) Chr 5: 140.85 – 141.01 Mb Chr 18: 37.13 – 37.32 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene. [5] [6]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome 5 that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [6]

Related Research Articles

<span class="mw-page-title-main">PCDHB16</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-16 is a protein that in humans is encoded by the PCDHB16 gene.

<span class="mw-page-title-main">PCDHB13</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.

<span class="mw-page-title-main">PCDHB5</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.

<span class="mw-page-title-main">PCDHB14</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.

<span class="mw-page-title-main">PCDHB11</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.

<span class="mw-page-title-main">PCDHB2</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-2 is a protein that in humans is encoded by the PCDHB2 gene.

<span class="mw-page-title-main">PCDHA12</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.

<span class="mw-page-title-main">PCDHA6</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.

<span class="mw-page-title-main">PCDHA4</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.

<span class="mw-page-title-main">PCDHA2</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-2 is a protein that in humans is encoded by the PCDHA2 gene.

<span class="mw-page-title-main">PCDHB9</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-9 is a protein that in humans is encoded by the PCDHB9 gene.

<span class="mw-page-title-main">PCDHB4</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.

<span class="mw-page-title-main">PCDHA5</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.

<span class="mw-page-title-main">PCDHGA12</span> Protein-coding gene in the species Homo sapiens

Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.

<span class="mw-page-title-main">PCDHB15</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.

<span class="mw-page-title-main">PCDHB12</span> Protein-coding gene in humans

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.

<span class="mw-page-title-main">PCDHB3</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene.

<span class="mw-page-title-main">PCDHAC2</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.

<span class="mw-page-title-main">PCDHA3</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.

<span class="mw-page-title-main">Protocadherin alpha 1</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000204961 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000103800 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
  6. 1 2 "Entrez Gene: PCDHA9 protocadherin alpha 9".

Further reading