PCDHB14

Last updated
PCDHB14
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PCDHB14 , PCDH-BETA14, protocadherin beta 14
External IDs OMIM: 606340 MGI: 2136758 HomoloGene: 134303 GeneCards: PCDHB14
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018934

NM_053145

RefSeq (protein)

NP_061757

NP_444375

Location (UCSC) Chr 5: 141.22 – 141.23 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene. [4] [5]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome 5. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections.

Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [5]

Related Research Articles

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Protocadherin beta-2 is a protein that in humans is encoded by the PCDHB2 gene.

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Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.

PCDHA6

Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.

PCDHA2

Protocadherin alpha-2 is a protein that in humans is encoded by the PCDHA2 gene.

PCDHA9

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PCDHB9

Protocadherin beta-9 is a protein that in humans is encoded by the PCDHB9 gene.

PCDHB7

Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene.

PCDHB4

Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.

PCDHGB7

Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene.

PCDHB15

Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.

PCDHB12 Protein-coding gene in humans

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.

PCDHB3

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120327 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID   10380929. S2CID   6014717.
  5. 1 2 "Entrez Gene: PCDHB14 protocadherin beta 14".

Further reading