PCDHB3

Last updated
PCDHB3
Identifiers
Aliases PCDHB3 , PCDH-BETA3, protocadherin beta 3
External IDs OMIM: 606329 MGI: 2136737 HomoloGene: 115665 GeneCards: PCDHB3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018937

NM_053128

RefSeq (protein)

NP_061760

NP_444358

Location (UCSC) Chr 5: 141.1 – 141.1 Mb Chr 18: 37.43 – 37.44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene. [5] [6]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily.

The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [6]

Related Research Articles

<span class="mw-page-title-main">PCDHB10</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-10 is a protein that in humans is encoded by the PCDHB10 gene.

<span class="mw-page-title-main">PCDHGC3</span> Protein-coding gene in the species Homo sapiens

Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.

<span class="mw-page-title-main">PCDH8</span>

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.

<span class="mw-page-title-main">PCDHB16</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-16 is a protein that in humans is encoded by the PCDHB16 gene.

<span class="mw-page-title-main">PCDHB13</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.

<span class="mw-page-title-main">PCDHB5</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.

<span class="mw-page-title-main">PCDHB14</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.

<span class="mw-page-title-main">PCDHB11</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.

<span class="mw-page-title-main">PCDHB2</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-2 is a protein that in humans is encoded by the PCDHB2 gene.

<span class="mw-page-title-main">PCDHA4</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.

<span class="mw-page-title-main">PCDHB9</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-9 is a protein that in humans is encoded by the PCDHB9 gene.

<span class="mw-page-title-main">PCDHB7</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene.

<span class="mw-page-title-main">PCDHB4</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.

<span class="mw-page-title-main">PCDHGA12</span> Protein-coding gene in the species Homo sapiens

Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.

<span class="mw-page-title-main">PCDHGB7</span> Protein-coding gene in the species Homo sapiens

Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene.

<span class="mw-page-title-main">PCDHGA11</span> Protein-coding gene in the species Homo sapiens

Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.

<span class="mw-page-title-main">PCDHB15</span> Protein-coding gene in the species Homo sapiens

Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.

<span class="mw-page-title-main">PCDHB12</span> Protein-coding gene in humans

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.

<span class="mw-page-title-main">PCDHAC2</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.

<span class="mw-page-title-main">Protocadherin alpha 1</span> Protein-coding gene in the species Homo sapiens

Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113205 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045498 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
  6. 1 2 "Entrez Gene: PCDHB3 protocadherin beta 3".

Further reading