PCDHB7

PCDHB7
Identifiers
Aliases	PCDHB7 , PCDH-BETA7, protocadherin beta 7
External IDs	OMIM: 606333 MGI: 2136750 HomoloGene: 32429 GeneCards: PCDHB7
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 141,172,644 bp [1] End 141,176,383 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B3 Start 37,606,593 bp [2] End 37,609,393 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura parietal pleura ganglionic eminence smooth muscle tissue ascending aorta popliteal artery lactiferous duct right coronary artery stromal cell of endometrium germinal epithelium Top expressed in Region I of hippocampus proper submandibular gland ciliary body sciatic nerve iris olfactory tubercle globus pallidus medial dorsal nucleus subiculum paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion chemical synaptic transmission synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56129 93886 Ensembl ENSG00000113212 ENSMUSG00000047033 UniProt Q9Y5E2 Q91Y04 RefSeq (mRNA) NM_018940 NM_053140 RefSeq (protein) NP_061763 NP_444370 Location (UCSC) Chr 5: 141.17 – 141.18 Mb Chr 18: 37.61 – 37.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene. ^{[5] [6]}

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113212 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047033 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
6. "Entrez Gene: PCDHB7 protocadherin beta 7".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi: 10.1101/gad.14.10.1169 . PMID   10817752. S2CID   44844497.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID   10835267.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC   311048 . PMID   11230163.
• Vanhalst K, Kools P, Vanden Eynde E, van Roy F (2001). "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number". FEBS Lett. 495 (1–2): 120–5. doi: 10.1016/S0014-5793(01)02372-9 . PMID   11322959. S2CID   36671435.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.