PCDHGA12 | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||
Aliases | PCDHGA12 , CDH21, FIB3, PCDH-GAMMA-A12, protocadherin gamma subfamily A, 12 | ||||||||||||||||||||||||
External IDs | OMIM: 603059 MGI: 1935229 HomoloGene: 134588 GeneCards: PCDHGA12 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 5: 141.43 – 141.51 Mb | Chr 18: 37.77 – 37.84 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
|
Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene. [5] [6]
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [6]
Protocadherin beta-10 is a protein that in humans is encoded by the PCDHB10 gene.
Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.
Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.
Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.
Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.
Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.
Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.
Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.
Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.
Protocadherin beta-9 is a protein that in humans is encoded by the PCDHB9 gene.
Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene.
Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.
Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene.
Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.
Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene.
Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.
Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.
Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.