PCID2

PCID2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T5X
Identifiers
Aliases	PCID2 , F10, PCI domain containing 2
External IDs	OMIM: 613713 MGI: 2443003 HomoloGene: 10168 GeneCards: PCID2
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q34 Start 113,177,536 bp [1] End 113,208,715 bp [1]
Gene ontology Molecular function • GO:0001948 protein binding • double-stranded DNA binding • RNA binding Cellular component • nuclear pore • transcriptionally active chromatin • transcription export complex 2 • cellular component • cell nucleus • cytoplasm • nuclear pore nuclear basket Biological process • positive regulation of B cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of mitotic cell cycle spindle assembly checkpoint • negative regulation of apoptotic process • spleen development • regulation of mRNA stability • negative regulation of cysteine-type endopeptidase activity • posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery • transcription elongation from RNA polymerase II promoter • poly(A)+ mRNA export from nucleus • nuclear retention of pre-mRNA at the site of transcription • protein transport • mRNA transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55795	234069
Ensembl	ENSG00000126226	ENSMUSG00000038542
UniProt	Q5JVF3	Q8BFV2
RefSeq (mRNA)	NM_001127202 NM_001127203 NM_001258212 NM_001258213 NM_018386 NM_001320655 NM_001320656 NM_001320657 NM_001320659 NM_001320660 NM_001353091 NM_001353092 NM_001353093 NM_001353094 NM_001353095	NM_178708
RefSeq (protein)	NP_001120674 NP_001120675 NP_001245142 NP_001307584 NP_001307585 NP_001307586 NP_001307588 NP_001307589 NP_060856 NP_001340020 NP_001340021 NP_001340022 NP_001340023 NP_001340024	NP_848823
Location (UCSC)	Chr 13: 113.18 – 113.21 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

PCI domain containing 2 is a protein that in humans is encoded by the PCID2 gene. ^[4]

Function

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000126226 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: PCI domain containing 2" . Retrieved 2017-12-13.

Further reading

• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC   2374985 . PMID   17672918.
• Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z (2014). "Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability". Stem Cells. 32 (3): 623–35. doi: 10.1002/stem.1580 . PMID   24167073.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.