PCID2

PCID2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T5X
Identifiers
Aliases	PCID2 , F10, PCI domain containing 2
External IDs	OMIM: 613713; MGI: 2443003; HomoloGene: 10168; GeneCards: PCID2; OMA:PCID2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q34 Start 113,177,536 bp [1] End 113,208,715 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A1.1 Start 13,127,189 bp [2] End 13,155,459 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte left ovary right ovary left testis right testis canal of the cervix body of uterus cerebellar hemisphere right hemisphere of cerebellum Top expressed in Ileal epithelium perirhinal cortex entorhinal cortex choroid plexus of fourth ventricle lactiferous gland otic placode CA3 field otic vesicle saccule internal carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding double-stranded DNA binding RNA binding Cellular component nuclear pore transcription export complex 2 cellular component nucleus cytoplasm nuclear pore nuclear basket Biological process positive regulation of B cell differentiation positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle spindle assembly checkpoint negative regulation of apoptotic process spleen development regulation of mRNA stability negative regulation of cysteine-type endopeptidase activity posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery transcription elongation from RNA polymerase II promoter poly(A)+ mRNA export from nucleus protein transport mRNA transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55795 234069 Ensembl ENSG00000126226 ENSMUSG00000038542 UniProt Q5JVF3 Q8BFV2 RefSeq (mRNA) NM_001127202 NM_001127203 NM_001258212 NM_001258213 NM_018386 NM_001320655 NM_001320656 NM_001320657 NM_001320659 NM_001320660 NM_001353091 NM_001353092 NM_001353093 NM_001353094 NM_001353095 NM_178708 RefSeq (protein) NP_001120674 NP_001120675 NP_001245142 NP_001307584 NP_001307585 NP_001307586 NP_001307588 NP_001307589 NP_060856 NP_001340020 NP_001340021 NP_001340022 NP_001340023 NP_001340024 NP_848823 Location (UCSC) Chr 13: 113.18 – 113.21 Mb Chr 8: 13.13 – 13.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PCI domain containing 2 is a protein that in humans is encoded by the PCID2 gene. ^[5]

Function

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000126226 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038542 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PCI domain containing 2" . Retrieved 2017-12-13.

Further reading

• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi: 10.1186/gb-2007-8-8-r154 . PMC   2374985 . PMID   17672918.
• Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z (2014). "Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability". Stem Cells. 32 (3): 623–35. doi: 10.1002/stem.1580 . PMID   24167073.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.