PCOLCE | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PCOLCE , PCPE, PCPE-1, PCPE1, procollagen C-endopeptidase enhancer | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600270 MGI: 105099 HomoloGene: 1946 GeneCards: PCOLCE | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene. [5] [6] [7]
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens activity. [7]
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase is an enzyme that in humans is encoded by the ADAMTS2 gene.
Bone morphogenetic protein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven isoforms of the protein created by alternate splicing.
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene.
Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.
Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene.
Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.
Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis .[supplied by OMIM]
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.
Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.
Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 is an enzyme that in humans is encoded by the MMP17 gene.
Vinexin is a protein that in humans is encoded by the SORBS3 gene.
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 is an enzyme that in humans is encoded by the PLOD3 gene.
Procollagen C-endopeptidase enhancer 2 is a protein that in humans is encoded by the PCOLCE2 gene.
Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.
Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene.
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.
Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.