PCOLCE2

PCOLCE2
Identifiers
Aliases	PCOLCE2 , PCPE2, procollagen C-endopeptidase enhancer 2
External IDs	OMIM: 607064 MGI: 1923727 HomoloGene: 8357 GeneCards: PCOLCE2
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q23 Start 142,815,922 bp [1] End 142,889,206 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E3.3 Start 95,519,654 bp [2] End 95,580,149 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibia synovial joint glomerulus right coronary artery metanephric glomerulus pericardium left coronary artery ascending aorta adipose tissue Top expressed in right lung lobe ascending aorta aortic valve olfactory epithelium carotid body sciatic nerve ankle rib interventricular septum left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding peptidase activator activity collagen binding Cellular component extracellular region Biological process positive regulation of peptidase activity cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26577 76477 Ensembl ENSG00000163710 ENSMUSG00000015354 UniProt Q9UKZ9 Q8R4W6 RefSeq (mRNA) NM_013363 NM_029620 RefSeq (protein) NP_037495 NP_083896 Location (UCSC) Chr 3: 142.82 – 142.89 Mb Chr 9: 95.52 – 95.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Procollagen C-endopeptidase enhancer 2 is a protein that in humans is encoded by the PCOLCE2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000163710 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015354 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu H, Acott TS, Wirtz MK (Sep 2000). "Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24". Genomics. 66 (3): 264–73. doi:10.1006/geno.2000.6229. PMID   10873381.
6. "Entrez Gene: PCOLCE2 procollagen C-endopeptidase enhancer 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi: 10.1053/joca.2001.0421 . PMID   11597177.
• Steiglitz BM, Greenspan DS (2002). "Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23". Cytogenet. Cell Genet. 95 (3–4): 244–5. doi:10.1159/000059356. PMID   12063410. S2CID   7566205.
• Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1". J. Biol. Chem. 277 (51): 49820–30. doi: 10.1074/jbc.M209891200 . PMID   12393877.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.