PCSK4

PCSK4
Identifiers
Aliases	PCSK4 , PC4, SPC5, proprotein convertase subtilisin/kexin type 4
External IDs	OMIM: 600487; MGI: 97514; HomoloGene: 22495; GeneCards: PCSK4; OMA:PCSK4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 1,481,428 bp [1] End 1,490,752 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 80,321,283 bp [2] End 80,329,498 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right uterine tube testicle anterior pituitary right lobe of liver right frontal lobe right lobe of thyroid gland left lobe of thyroid gland olfactory zone of nasal mucosa Top expressed in spermatid spermatocyte seminiferous tubule internal carotid artery external carotid artery neural layer of retina outer nuclear layer embryo proximal tubule embryo More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity protein binding serine-type endopeptidase activity Cellular component integral component of membrane membrane acrosomal membrane cytoplasmic vesicle acrosomal vesicle trans-Golgi network integral component of Golgi membrane Biological process proteolysis binding of sperm to zona pellucida sperm capacitation acrosome reaction fertilization reproductive process protein processing peptide hormone processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54760 18551 Ensembl ENSG00000115257 ENSMUSG00000020131 UniProt Q6UW60 P29121 RefSeq (mRNA) NM_017573 NM_001395257 NM_008793 RefSeq (protein) NP_060043 NP_032819 Location (UCSC) Chr 19: 1.48 – 1.49 Mb Chr 10: 80.32 – 80.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID   7782070.
6. "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

Further reading

• Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions". Biochimie. 76 (3–4): 197–209. doi:10.1016/0300-9084(94)90147-3. PMID   7819324.
• Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression". Mol. Carcinog. 28 (2): 63–9. doi:10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C. PMID   10900462. S2CID   22849623.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi: 10.1073/pnas.95.5.2192 . PMC   19292 . PMID   9482861.
• Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi: 10.1016/S1097-2765(00)80074-X . PMID   9660958.
• Li M, Mbikay M, Nakayama K, et al. (2001). "Prohormone convertase PC4 processes the precursor of PACAP in the testis". Ann. N. Y. Acad. Sci. 921: 333–9. doi:10.1111/j.1749-6632.2000.tb06988.x. PMID   11193847. S2CID   46125753.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Qiu Q, Basak A, Mbikay M, et al. (2005). "Role of pro-IGF-II processing by proprotein convertase 4 in human placental development". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 11047–52. Bibcode:2005PNAS..10211047Q. doi: 10.1073/pnas.0502357102 . PMC   1182422 . PMID   16040806.