PCYT1B

PCYT1B
Identifiers
Aliases	PCYT1B , CCTB, CTB, phosphate cytidylyltransferase 1, choline, beta, phosphate cytidylyltransferase 1B, choline
External IDs	OMIM: 300948 MGI: 2147987 HomoloGene: 3564 GeneCards: PCYT1B
Gene location (Human)
Chr.	X chromosome (human)
End	24,672,677 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	92,793,557 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; amygdala; ; nucleus accumbens; ; cingulate gyrus; ; corpus callosum; ; caudate nucleus; ; putamen; ; entorhinal cortex; ; dorsolateral prefrontal cortex;
	Top expressed in
	secondary oocyte; ; otolith organ; ; utricle; ; ganglionic eminence; ; piriform cortex; ; respiratory epithelium; ; olfactory epithelium; ; pontine nuclei; ; visual cortex; ; anterior horn of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotidyltransferase activity ; catalytic activity ; transferase activity ; choline-phosphate cytidylyltransferase activity ; phosphatidylcholine binding ;
Cellular component	endoplasmic reticulum membrane ; cytoplasm ; endoplasmic reticulum ;
Biological process	phospholipid biosynthetic process ; phosphatidylcholine biosynthetic process ; biosynthetic process ; spermatogenesis ; ovarian follicle development ; lipid metabolism ; CDP-choline pathway ;
	Sources:Amigo / QuickGO
Orthologs
	9468
	236899
	ENSG00000102230
	ENSMUSG00000035246
	Q9Y5K3
	Q811Q9
	NM_001163264 ; NM_001163265 ; NM_004845
	NM_177546 ; NM_211138
	NP_001156736 ; NP_001156737 ; NP_004836
	NP_808214 ; NP_997593
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

Choline-phosphate cytidylyltransferase B is an enzyme that in humans is encoded by the PCYT1B gene.^[5]^[6]

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The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid phosphatidylethanolamine (PE).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102230 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035246 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lykidis A, Murti KG, Jackowski S (Jul 1998). "Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase". J Biol Chem. 273 (22): 14022–9. doi: 10.1074/jbc.273.22.14022 . PMID 9593753.
↑ "Entrez Gene: PCYT1B phosphate cytidylyltransferase 1, choline, beta".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Llorca O, Martín-Benito J, Gómez-Puertas P, et al. (2002). "Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". J. Struct. Biol. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270.
McCormack EA, Llorca O, Carrascosa JL, et al. (2002). "Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT". J. Struct. Biol. 135 (2): 198–204. doi:10.1006/jsbi.2001.4385. PMID 11580269.
Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant". J. Biol. Chem. 274 (38): 26992–7001. doi: 10.1074/jbc.274.38.26992 . PMID 10480912.
Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102230 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035246 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9593753-5] Lykidis A, Murti KG, Jackowski S (Jul 1998). "Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase". J Biol Chem. 273 (22): 14022–9. doi: 10.1074/jbc.273.22.14022 . PMID 9593753.

[entrez-6] "Entrez Gene: PCYT1B phosphate cytidylyltransferase 1, choline, beta".

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PCYT1B

Related Research Articles

References

Further reading