PDCD2

PDCD2
Identifiers
Aliases	PDCD2 , RP8, ZMYND7, programmed cell death 2
External IDs	OMIM: 600866 MGI: 104643 HomoloGene: 1951 GeneCards: PDCD2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	170,584,692 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,747,563 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; rectum; ; Achilles tendon; ; body of stomach; ; monocyte; ; right coronary artery; ; ganglionic eminence; ; islet of Langerhans; ; left coronary artery; ; minor salivary gland;
	Top expressed in
	fossa; ; primitive streak; ; facial motor nucleus; ; condyle; ; medial ganglionic eminence; ; epithelium of stomach; ; morula; ; hair follicle; ; Paneth cell; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding ; DNA binding ; protein binding ; metal ion binding ;
Cellular component	cytoplasm ; extracellular exosome ; nucleus ;
Biological process	positive regulation of apoptotic process ; positive regulation of hematopoietic stem cell proliferation ; regulation of hematopoietic progenitor cell differentiation ; activation of cysteine-type endopeptidase activity involved in apoptotic process ; programmed cell death ; apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	5134
	18567
	ENSG00000071994
	ENSMUSG00000014771
	Q16342
	P46718
NM_001199461 ; NM_001199462 ; NM_001199463 ; NM_001199464 ; NM_002598 ;
	NM_144781 ; NM_001363655
	NM_008799
NP_001186390 ; NP_001186391 ; NP_001186392 ; NP_001186393 ; NP_002589 ;
	NP_659005 ; NP_001350584
	NP_032825
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene.^[5]^[6]

Function

This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Six transcripts encoding different proteins have been identified.^[6]

Interactions

PDCD2 has been shown to interact with Host cell factor C1 ^[7] and Parkin (ligase).^[8]

Related Research Articles

Bcl-6 is a protein that in humans is encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper cells proliferation. BCL6 has three evolutionary conserved structural domains. The interaction of these domains with corepressors allows for germinal center development and leads to B cell proliferation.

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

Host cell factor 1, also known as VP16-accessory protein, is a protein that in humans is encoded by the HCFC1 gene.

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.

Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an oncomiR, MIRN21.

Cytochrome c1, heme protein, mitochondrial (CYC1), also known as UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4, or Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit is a protein that in humans is encoded by the CYC1 gene. CYC1 is a respiratory subunit of Ubiquinol Cytochrome c Reductase, which is located in the inner mitochondrial membrane and is part of the electron transport chain. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.

DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.

BCL-6 corepressor is a protein that in humans is encoded by the BCOR gene.

Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene. It is part of the EAF family of proteins.

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.

B-cell CLL/lymphoma 6 member B protein is a protein that in humans is encoded by the BCL6B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000071994 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014771 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kawakami T, Furukawa Y, Sudo K, Saito H, Takami S, Takahashi E, Nakamura Y (Aug 1995). "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death". Cytogenetics and Cell Genetics. 71 (1): 41–3. doi:10.1159/000134058. PMID 7606924.
1 2 "Entrez Gene: PDCD2 programmed cell death 2".
↑ Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi: 10.1038/sj.onc.1205647 . PMID 12149646.
↑ Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N (Feb 2009). "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease". FEBS Letters. 583 (3): 521–5. doi:10.1016/j.febslet.2008.12.055. hdl: 1721.1/96274 . PMID 19146857. S2CID 7121769.

Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, Kim DC, Simone F, Birkenbach M, Montag A, Sadhu A, Zeleznik-Le N, McKeithan TW (Mar 2002). "The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2860–5. Bibcode:2002PNAS...99.2860B. doi: 10.1073/pnas.042702599 . PMC 122438 . PMID 11854457.
Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi: 10.1038/sj.onc.1205647 . PMID 12149646.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Chen Q, Qian K, Yan C (Dec 2005). "Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells". Molecular and Cellular Biochemistry. 280 (1–2): 185–91. doi:10.1007/s11010-005-8910-z. PMID 16311922. S2CID 6208880.
Baron BW, Zeleznik-Le N, Baron MJ, Theisler C, Huo D, Krasowski MD, Thirman MJ, Baron RM, Baron JM (May 2007). "Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas". Proceedings of the National Academy of Sciences of the United States of America. 104 (18): 7449–54. Bibcode:2007PNAS..104.7449B. doi: 10.1073/pnas.0701770104 . PMC 1863460 . PMID 17468402.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000071994 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014771 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7606924-5] Kawakami T, Furukawa Y, Sudo K, Saito H, Takami S, Takahashi E, Nakamura Y (Aug 1995). "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death". Cytogenetics and Cell Genetics. 71 (1): 41–3. doi:10.1159/000134058. PMID 7606924.

[entrez-6] 1 2 "Entrez Gene: PDCD2 programmed cell death 2".

[pmid12149646-7] Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi: 10.1038/sj.onc.1205647 . PMID 12149646.

[pmid19146857-8] Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N (Feb 2009). "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease". FEBS Letters. 583 (3): 521–5. doi:10.1016/j.febslet.2008.12.055. hdl: 1721.1/96274 . PMID 19146857. S2CID 7121769.

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PDCD2

Contents

Function

Interactions

Related Research Articles

References

Further reading