PDCD4

PDCD4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ
Identifiers
Aliases	PDCD4 , H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
External IDs	OMIM: 608610 MGI: 107490 HomoloGene: 7879 GeneCards: PDCD4
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q25.2 Start 110,871,795 bp [1] End 110,900,006 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 D2|19 48.73 cM Start 53,880,662 bp [2] End 53,918,291 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen rectum right lobe of thyroid gland left lobe of thyroid gland minor salivary gland transverse colon right uterine tube anterior pituitary Achilles tendon Top expressed in lacrimal gland submandibular gland parotid gland pyloric antrum aortic valve ascending aorta pineal gland corneal stroma seminal vesicula blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm nucleus cytosol nucleoplasm Biological process regulation of protein metabolic process negative regulation of cell cycle negative regulation of apoptotic process negative regulation of transcription, DNA-templated negative regulation of JUN kinase activity positive regulation of smooth muscle cell apoptotic process negative regulation of myofibroblast differentiation apoptotic process positive regulation of endothelial cell apoptotic process BMP signaling pathway epithelial to mesenchymal transition involved in cardiac fibroblast development negative regulation of vascular associated smooth muscle cell differentiation positive regulation of inflammatory response cellular response to lipopolysaccharide negative regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling interleukin-12-mediated signaling pathway negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27250 18569 Ensembl ENSG00000150593 ENSMUSG00000024975 UniProt Q53EL6 Q61823 RefSeq (mRNA) NM_145341 NM_001199492 NM_014456 NM_001168491 NM_001168492 NM_011050 RefSeq (protein) NP_001186421 NP_055271 NP_663314 NP_001161963 NP_001161964 NP_035180 Location (UCSC) Chr 10: 110.87 – 110.9 Mb Chr 19: 53.88 – 53.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. ^{[5] [6]} It is one of the targets of an oncomiR, MIRN21. ^[7]

Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. ^[6]

Interactions

PDCD4 has been shown to interact with RPS13, ^[8] ribosomal protein L5, ^[8] p62, LC3 and Ubiquitin [9]

References

1. GRCh38: Ensembl release 89: ENSG00000150593 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024975 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of Immunology. 161 (7): 3493–500. doi:10.4049/jimmunol.161.7.3493. PMID   9759869. S2CID   21776266.
6. EntrezGene 27250
7. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi: 10.1074/jbc.M707224200 . PMID   17991735.
8. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID   12054647.

9.  Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R,Takahashi H,  Anzai K, Matsuhashi S (2020). "Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy". Cells. 9(1): 218. doi.org/10.3390/cells9010218.

Further reading

• Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B (2004). "Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells". Annals of the New York Academy of Sciences. 1014 (1): 220–1. Bibcode:2004NYASA1014..220G. doi:10.1196/annals.1294.024. PMID   15153438. S2CID   9284462.
• Maruyama K, Sugano S (1994). "Oligo-capping: A simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T (1995). "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death". Gene. 166 (2): 297–301. doi:10.1016/0378-1119(95)00607-9. PMID   8543179.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z (1999). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody". Pathology International. 49 (12): 1067–77. doi:10.1046/j.1440-1827.1999.00995.x. PMID   10632927. S2CID   968499.
• Soejima H, Miyoshi O, Yoshinaga H, Masaki Z, Ozaki I, Kajiwara S, Niikawa N, Matsuhashi S, Mukai T (1999). "Assignment¹ of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization". Cytogenetic and Genome Research. 87 (1–2): 113–4. doi:10.1159/000015408. PMID   10640828. S2CID   34560093.
• Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID   12054647.
• Chen Y, Knösel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis". The Journal of Pathology. 200 (5): 640–6. doi:10.1002/path.1378. PMID   12898601. S2CID   25899458.
• Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH (2004). "A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A". Molecular and Cellular Biology. 24 (9): 3894–906. doi:10.1128/MCB.24.9.3894-3906.2004. PMC   387765 . PMID   15082783.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B (2004). "Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1". AJP: Cell Physiology. 287 (6): C1541–6. doi:10.1152/ajpcell.00025.2004. PMID   15317660. S2CID   83565566.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2004). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y (2005). "Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein". Cancer Research. 65 (24): 11282–6. doi: 10.1158/0008-5472.CAN-05-3469 . PMID   16357133.
• Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH (2006). "Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion". Molecular and Cellular Biology. 26 (4): 1297–306. doi:10.1128/MCB.26.4.1297-1306.2006. PMC   1367180 . PMID   16449643.