PDE7A

PDE7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZKL, 3G3N, 4PM0, 4Y2B
Identifiers
Aliases	PDE7A , HCP1, PDE7, phosphodiesterase 7A
External IDs	OMIM: 171885 MGI: 1202402 HomoloGene: 1956 GeneCards: PDE7A
EC number	3.1.4.53
Gene location (Human)
Chr.	Chromosome 8 (human)
End	65,842,322 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	19,365,486 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; thymus; ; lymph node; ; gastrocnemius muscle; ; deltoid muscle; ; appendix; ; left ventricle; ; biceps brachii; ; quadriceps femoris muscle; ; tibialis anterior muscle;
	Top expressed in
	left lung lobe; ; spermatocyte; ; conjunctival fornix; ; left colon; ; ganglionic eminence; ; primitive streak; ; spermatid; ; condyle; ; maxillary prominence; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity ; metal ion binding ; phosphoric diester hydrolase activity ; 3',5'-cyclic-nucleotide phosphodiesterase activity ; 3',5'-cyclic-AMP phosphodiesterase activity ;
Cellular component	cytosol ; cytoplasm ;
Biological process	cAMP catabolic process ; signal transduction ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	5150
	18583
	ENSG00000205268
	ENSMUSG00000069094
	Q13946
	P70453
	NM_001242318 ; NM_002603 ; NM_002604
	NM_001122759 ; NM_008802
	NP_001229247 ; NP_002594
	NP_001116231 ; NP_032828
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.^[5]^[6]^[7] Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

Related Research Articles

<span class="mw-page-title-main">Cyclic nucleotide</span> Cyclic nucleic acid

A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides, cyclic nucleotides are composed of three functional groups: a sugar, a nitrogenous base, and a single phosphate group. As can be seen in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic' portion consists of two bonds between the phosphate group and the 3' and 5' hydroxyl groups of the sugar, very often a ribose.

The PDE2 enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families. The different PDEs of the same family are functionally related despite the fact that their amino acid sequences show considerable divergence. The PDEs have different substrate specificities. Some are cAMP selective hydrolases, others are cGMP selective hydrolases and the rest can hydrolyse both cAMP and cGMP.

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.

cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene.

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene.

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.

2′,3′-Cyclic-nucleotide 3'-phosphodiesterase is an enzyme that in humans is encoded by the CNP gene.

PDE7B is a mammalian gene that encodes a 3'5'-cyclic nucleotide phosphodiesterase (PDE) that converts 3'5'-cyclic adenosine monophosphate (cAMP) to 5'AMP as part of cyclic nucleotide signaling pathways. There are 21 PDE genes in mammals that are pharmacologically-grouped into 11 families based on their biochemical characteristics and sequence conservation. The PDE7 family is composed of PDEs encoded by two genes, PDE7A and PDE7B. These PDEs are highly specific for cAMP relative to cGMP.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000205268 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069094 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. doi: 10.1016/S0021-9258(18)31474-1 . PMID 8389765.
↑ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
↑ "Entrez Gene: PDE7A phosphodiesterase 7A".

Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. S2CID 19182571.
Han P, Zhu X, Michaeli T (1997). "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart". J. Biol. Chem. 272 (26): 16152–7. doi: 10.1074/jbc.272.26.16152 . PMID 9195912.
Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.
Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353.
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID 11156964. S2CID 26315564.
Glavas NA, Ostenson C, Schaefer JB, Vasta V, Beavo JA (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. Bibcode:2001PNAS...98.6319G. doi: 10.1073/pnas.101131098 . PMC 33466 . PMID 11371644.
Lee R, Wolda S, Moon E, Esselstyn J, Hertel C, Lerner A (2002). "PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP". Cell. Signal. 14 (3): 277–84. doi:10.1016/S0898-6568(01)00250-9. PMID 11812656.
Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kikkawa H, Omori K, Kaminuma O (2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors". Clin. Exp. Immunol. 128 (3): 460–6. doi:10.1046/j.1365-2249.2002.01856.x. PMC 1906253 . PMID 12067300.
Smith SJ, Brookes-Fazakerley S, Donnelly LE, Barnes PJ, Barnette MS, Giembycz MA (2003). "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2): L279–89. doi:10.1152/ajplung.00170.2002. PMID 12388353.
Torras-Llort M, Azorín F (2003). "Functional characterization of the human phosphodiesterase 7A1 promoter". Biochem. J. 373 (Pt 3): 835–43. doi:10.1042/BJ20021829. PMC 1223549 . PMID 12737631.
Wang H, Liu Y, Chen Y, Robinson H, Ke H (2005). "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7". J. Biol. Chem. 280 (35): 30949–55. doi: 10.1074/jbc.M504398200 . PMID 15994308.
Sánchez AI, Meneses R, Mínguez JM, Núñez A, Castillo RR, Filace F, Burgos C, Vaquero JJ, Álvarez-Builla J, Cortés-Cabrera A, Gago F, Terricabras E, Segarra V (2014). "Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold". Org. Biomol. Chem. 12 (24): 4233–42. doi:10.1039/c4ob00175c. PMID 24838636.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000205268 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069094 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8389765-5] Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. doi: 10.1016/S0021-9258(18)31474-1 . PMID 8389765.

[pmid9521885-6] Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.

[entrez-7] "Entrez Gene: PDE7A phosphodiesterase 7A".

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PDE7A

Related Research Articles

References

Further reading