PDLIM2

PDLIM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PA1, 3PDV
Identifiers
Aliases	PDLIM2 , MYSTIQUE, SLIM, PDZ and LIM domain 2
External IDs	OMIM: 609722 MGI: 2384850 HomoloGene: 11006 GeneCards: PDLIM2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,598,025 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,415,130 bp
RNA expression pattern
	Top expressed in
	spleen; ; ascending aorta; ; skin of abdomen; ; right coronary artery; ; stromal cell of endometrium; ; nipple; ; tibial nerve; ; upper lobe of left lung; ; popliteal artery; ; left coronary artery;
	Top expressed in
	esophagus; ; lip; ; right lung; ; intestinal villus; ; right lung lobe; ; calvaria; ; left lung; ; left lung lobe; ; sciatic nerve; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; metal ion binding ; actin binding ; muscle alpha-actinin binding ;
Cellular component	cytoplasm ; cytoskeleton ; nucleus ; stress fiber ; Z disc ; filamentous actin ;
Biological process	heart development ; actin cytoskeleton organization ; muscle structure development ;
	Sources:Amigo / QuickGO
Orthologs
	64236
	213019
	ENSG00000120913
	ENSMUSG00000022090
	Q96JY6
	Q8R1G6
	NM_198042 ; NM_021630 ; NM_176871 ; NM_001368120
	NM_001253736 ; NM_145978
	NP_067643 ; NP_789847 ; NP_932159 ; NP_001355049
	NP_001240665 ; NP_666090
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

PDZ and LIM domain protein 2 is a protein that in humans is encoded by the PDLIM2 gene.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120913 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022090 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PDLIM2 PDZ and LIM domain 2 (mystique)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi: 10.1093/dnares/7.6.357 . PMID 11214971.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi: 10.1074/jbc.M210455200 . PMID 12493773.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.
Loughran G, Healy NC, Kiely PA, et al. (2005). "Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth". Mol. Biol. Cell. 16 (4): 1811–22. doi:10.1091/mbc.E04-12-1052. PMC 1073663 . PMID 15659642.
Tanaka T, Grusby MJ, Kaisho T (2007). "PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit". Nat. Immunol. 8 (6): 584–91. doi:10.1038/ni1464. PMID 17468759. S2CID 13357628.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120913 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022090 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PDLIM2 PDZ and LIM domain 2 (mystique)".

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PDLIM2

Related Research Articles

References

Further reading