PDS5A

PDS5A
Identifiers
Aliases	PDS5A , SCC-112, SCC112, PIG54, PDS5 cohesin associated factor A
External IDs	OMIM: 613200; MGI: 1918771; HomoloGene: 22877; GeneCards: PDS5A; OMA:PDS5A - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p14 Start 39,822,863 bp [1] End 39,977,956 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C3.1 Start 65,763,064 bp [2] End 65,855,616 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium epithelium of nasopharynx Achilles tendon tonsil gingival epithelium epithelium of colon Epithelium of choroid plexus cartilage tissue seminal vesicula bone marrow cells Top expressed in tail of embryo genital tubercle ventricular zone epiblast primitive streak thymus lacrimal gland cumulus cell renal corpuscle Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol chromatin plasma membrane chromosome, centromeric region nucleoplasm chromosome nucleus Biological process cell division cell cycle negative regulation of DNA replication mitotic sister chromatid cohesion DNA repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23244 71521 Ensembl ENSG00000121892 ENSMUSG00000029202 UniProt Q29RF7 Q6A026 RefSeq (mRNA) NM_001100399 NM_001100400 NM_015200 NM_001081321 NM_027818 RefSeq (protein) NP_001093869 NP_001093870 n/a Location (UCSC) Chr 4: 39.82 – 39.98 Mb Chr 5: 65.76 – 65.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000121892 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029202 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (Dec 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC   2169443 . PMID   11076961.
6. Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J Cell Sci. 118 (Pt 10): 2133–41. doi: 10.1242/jcs.02355 . PMID   15855230.
7. "Entrez Gene: SCC-112 SCC-112 protein".

Further reading

• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
• Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–82. doi: 10.1074/jbc.M103364200 . PMID   11590136.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kumar D, Sakabe I, Patel S, et al. (2004). "SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas". Gene. 328: 187–96. doi:10.1016/j.gene.2003.12.013. PMID   15019998.
• Rankin S, Ayad NG, Kirschner MW (2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol. Cell. 18 (2): 185–200. doi: 10.1016/j.molcel.2005.03.017 . PMID   15837422.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.