PDZK1IP1

PDZK1IP1
Identifiers
Aliases	PDZK1IP1 , DD96, MAP17, SPAP, PDZK1 interacting protein 1
External IDs	OMIM: 607178; MGI: 1914432; HomoloGene: 4213; GeneCards: PDZK1IP1; OMA:PDZK1IP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p33 Start 47,183,582 bp [1] End 47,191,044 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 114,945,905 bp [2] End 114,951,096 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in metanephric glomerulus minor salivary glands kidney tubule palpebral conjunctiva skin of abdomen gallbladder human kidney skin of leg gums body of pancreas Top expressed in right kidney human kidney proximal tubule corneal stroma esophagus medullary collecting duct lip conjunctival fornix gastrula left colon More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10158 67182 Ensembl ENSG00000162366 ENSMUSG00000028716 UniProt Q13113 Q9CQH0 RefSeq (mRNA) NM_005764 NM_001164557 NM_001164558 NM_026018 RefSeq (protein) NP_005755 NP_001158029 NP_001158030 NP_080294 Location (UCSC) Chr 1: 47.18 – 47.19 Mb Chr 4: 114.95 – 114.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PDZK1-interacting protein 1 is a protein that in humans is encoded by the PDZK1IP1 gene. ^{[5] [6] [7] [8] [9]}

Interactions

PDZK1IP1 has been shown to interact with PDZK1. ^{[7] [8] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000162366 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028716 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kocher O, Cheresh P, Brown LF, Lee SW (Feb 1999). "Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique". Clin. Cancer Res. 1 (10): 1209–15. PMID   9815914.
6. Kocher O, Cheresh P, Lee SW (Sep 1996). "Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth". Am. J. Pathol. 149 (2): 493–500. PMC   1865305 . PMID   8701988.
7. Silver DL, Wang N, Vogel S (Jul 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi: 10.1074/jbc.M304109200 . PMID   12754212.
8. Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (Sep 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784-91. doi:10.1152/ajprenal.00109.2003. PMID   12837682. S2CID   25450845.
9. "Entrez Gene: PDZK1IP1 PDZK1 interacting protein 1".
10. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID   14531806.

Further reading

• Kocher O, Comella N, Tognazzi K, Brown LF (1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab. Invest. 78 (1): 117–25. PMID   9461128.
• Göttgens B, Barton LM, Chapman MA, Sinclair AM, Knudsen B, Grafham D, Gilbert JG, Rogers J, Bentley DR, Green AR (2002). "Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci". Genome Res. 12 (5): 749–59. doi:10.1101/gr.45502. PMC   186570 . PMID   11997341.
• Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID   14531806.
• Guijarro MV, Castro ME, Romero L, Moneo V, Carnero A (2007). "Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest". J. Cell. Biochem. 101 (1): 112–21. doi: 10.1002/jcb.21163 . hdl: 10641/3690 . PMID   17230460. S2CID   20793096.
• Guijarro MV, Leal JF, Fominaya J, Blanco-Aparicio C, Alonso S, Lleonart M, Castellvi J, Ruiz L, Ramon y Cajal S, Carnero A (2007). "MAP17 overexpression is a common characteristic of carcinomas". Carcinogenesis. 28 (8): 1646–52. doi: 10.1093/carcin/bgm083 . PMID   17426052.
• Guijarro MV, Leal JF, Blanco-Aparicio C, Alonso S, Fominaya J, Lleonart M, Castellvi J, Ramon y Cajal S, Carnero A (2007). "MAP17 enhances the malignant behavior of tumor cells through ROS increase". Carcinogenesis. 28 (10): 2096–104. doi: 10.1093/carcin/bgm124 . PMID   17548903.

External links

• PDZK1IP1 human gene location in the UCSC Genome Browser .
• PDZK1IP1 human gene details in the UCSC Genome Browser .