PGK1

PGK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WZB, 2WZC, 2WZD, 2X13, 2X14, 2X15, 2XE6, 2XE7, 2XE8, 2Y3I, 2YBE, 2ZGV, 3C39, 3C3A, 3C3B, 3C3C, 3ZOZ, 4AXX, 4O33 Contents Interactive pathway map ; References ; Further reading ; External links ;
Identifiers
Aliases	PGK1 , HEL-S-68p, MIG10, PGKA, phosphoglycerate kinase 1
External IDs	OMIM: 311800; MGI: 97555; HomoloGene: 21542; GeneCards: PGK1; OMA:PGK1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	78,129,295 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,247,305 bp
RNA expression pattern
	Top expressed in
	tibia; ; germinal epithelium; ; right ventricle; ; pericardium; ; parotid gland; ; Skeletal muscle tissue of rectus abdominis; ; pons; ; lateral nuclear group of thalamus; ; trabecular bone; ; palpebral conjunctiva;
	Top expressed in
	quadriceps femoris muscle; ; epiblast; ; muscle of thigh; ; skeletal muscle tissue; ; neural layer of retina; ; tail of embryo; ; granulocyte; ; ventricular zone; ; embryo; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein binding ; ATP binding ; kinase activity ; phosphoglycerate kinase activity ; protein-disulfide reductase (NAD(P)) activity ; ADP binding ;
Cellular component	cytoplasm ; membrane raft ; cytosol ; extracellular exosome ; membrane ; extracellular space ;
Biological process	gluconeogenesis ; epithelial cell differentiation ; phosphorylation ; canonical glycolysis ; glycolytic process ; negative regulation of angiogenesis ; plasminogen activation ; cellular response to hypoxia ; response to hypoxia ; chemical synaptic transmission ; myoblast fusion ; somatic muscle development ; muscle cell cellular homeostasis ; positive regulation of oxidative phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	5230
	18655
	ENSG00000102144
	ENSMUSG00000062070
	P00558
	P09411
	NM_000291
	NM_008828
	NP_000282
	NP_032854
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 18, 2025

Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene.^[5]^[6]^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102144 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062070 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Michelson AM, Markham AF, Orkin SH (May 1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase". Proc Natl Acad Sci U S A. 80 (2): 472–6. Bibcode:1983PNAS...80..472M. doi: 10.1073/pnas.80.2.472 . PMC 393400 . PMID 6188151.
↑ Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene. 32 (3): 409–17. doi:10.1016/0378-1119(84)90016-7. PMID 6099325.
↑ "Entrez Gene: PGK1 phosphoglycerate kinase 1".

Vishwanatha JK, Jindal HK, Davis RG (1992). "The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells". J. Cell Sci. 101. ( Pt 1): 25–34. doi:10.1242/jcs.101.1.25. PMID 1533225.
Fujii H, Kanno H, Hirono A, et al. (1992). "A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria". Blood. 79 (6): 1582–5. doi: 10.1182/blood.V79.6.1582.1582 . PMID 1547346.
Maeda M, Bawle EV, Kulkarni R, et al. (1992). "Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation". Blood. 79 (10): 2759–62. doi: 10.1182/blood.V79.10.2759.bloodjournal79102759 . PMID 1586722.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Kumble KD, Vishwanatha JK (1992). "Immunoelectron microscopic analysis of the intracellular distribution of primer recognition proteins, annexin 2 and phosphoglycerate kinase, in normal and transformed cells". J. Cell Sci. 99. ( Pt 4) (4): 751–8. doi:10.1242/jcs.99.4.751. PMID 1837552.
Maeda M, Yoshida A (1991). "Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3". Blood. 77 (6): 1348–52. doi: 10.1182/blood.V77.6.1348.1348 . PMID 2001457.
Jindal HK, Vishwanatha JK (1990). "Functional identity of a primer recognition protein as phosphoglycerate kinase". J. Biol. Chem. 265 (12): 6540–3. doi: 10.1016/S0021-9258(19)39179-3 . PMID 2324090.
Johnson P, Friedmann T (1990). "Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK". Gene. 88 (2): 207–13. doi:10.1016/0378-1119(90)90033-N. PMID 2347494.
Pfeifer GP, Steigerwald SD, Mueller PR, et al. (1989). "Genomic sequencing and methylation analysis by ligation mediated PCR". Science. 246 (4931): 810–3. Bibcode:1989Sci...246..810P. doi:10.1126/science.2814502. PMID 2814502.
Michelson AM, Blake CC, Evans ST, Orkin SH (1985). "Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain". Proc. Natl. Acad. Sci. U.S.A. 82 (20): 6965–9. Bibcode:1985PNAS...82.6965M. doi: 10.1073/pnas.82.20.6965 . PMC 391290 . PMID 2995995.
McCarrey JR, Thomas K (1987). "Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene". Nature. 326 (6112): 501–5. Bibcode:1987Natur.326..501M. doi:10.1038/326501a0. PMID 3453121. S2CID 4353366.
Fujii H, Yoshida A (1981). "Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia". Proc. Natl. Acad. Sci. U.S.A. 77 (9): 5461–5. doi: 10.1073/pnas.77.9.5461 . PMC 350080 . PMID 6933565.
Fujii H, Chen SH, Akatsuka J, et al. (1981). "Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia". Proc. Natl. Acad. Sci. U.S.A. 78 (4): 2587–90. Bibcode:1981PNAS...78.2587F. doi: 10.1073/pnas.78.4.2587 . PMC 319394 . PMID 6941312.
Huang IY, Welch CD, Yoshida A (1980). "Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence". J. Biol. Chem. 255 (13): 6412–20. doi: 10.1016/S0021-9258(18)43754-4 . PMID 7391027.
Fujii H, Krietsch WK, Yoshida A (1980). "A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency". J. Biol. Chem. 255 (13): 6421–3. doi: 10.1016/S0021-9258(18)43755-6 . PMID 7391028.
Huang IY, Fujii H, Yoshida A (1981). "Structure and function of normal and variant human phosphoglycerate kinase". Hemoglobin. 4 (5–6): 601–9. doi:10.3109/03630268008997730. PMID 7440217.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Hershkovitz M, Riggs AD (1995). "Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2379–83. Bibcode:1995PNAS...92.2379H. doi: 10.1073/pnas.92.6.2379 . PMC 42487 . PMID 7892275.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphoglycerate kinase 1

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

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[WikiPathways-8] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102144 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062070 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6188151-5] Michelson AM, Markham AF, Orkin SH (May 1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase". Proc Natl Acad Sci U S A. 80 (2): 472–6. Bibcode:1983PNAS...80..472M. doi: 10.1073/pnas.80.2.472 . PMC 393400 . PMID 6188151.

[pmid6099325-6] Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene. 32 (3): 409–17. doi:10.1016/0378-1119(84)90016-7. PMID 6099325.

[7] "Entrez Gene: PGK1 phosphoglycerate kinase 1".

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[§ 1]

PGK1

Contents

Interactive pathway map

References

Further reading

External links