PHAX

PHAX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XC7
Identifiers
Aliases	PHAX , RNUXA, phosphorylated adaptor for RNA export
External IDs	OMIM: 604924 MGI: 1891839 HomoloGene: 10558 GeneCards: PHAX
Gene location (Human)
Chr.	Chromosome 5 (human)
End	126,627,252 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	56,720,784 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; ganglionic eminence; ; stromal cell of endometrium; ; smooth muscle tissue; ; islet of Langerhans; ; corpus callosum; ; internal globus pallidus; ; prefrontal cortex; ; amniotic fluid;
	Top expressed in
	otic placode; ; saccule; ; neural tube; ; abdominal wall; ; primitive streak; ; morula; ; medial ganglionic eminence; ; interventricular septum; ; maxillary prominence; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; toxic substance binding ; RNA binding ;
Cellular component	nucleoplasm ; Cajal body ; nucleus ; cytosol ; neuronal cell body ; cytoplasm ; centrosome ;
Biological process	protein transport ; snRNA export from nucleus ; snRNA transcription by RNA polymerase II ; nuclear export ;
	Sources:Amigo / QuickGO
Orthologs
	51808
	56698
	ENSG00000164902
	ENSMUSG00000008301
	Q9H814
	Q9JJT9
	NM_032177
	NM_001162989 ; NM_019996
	NP_115553
	NP_001156461 ; NP_064380
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 14, 2024

Phosphorylated adapter RNA export protein is a protein that in humans is encoded by the PHAX gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164902 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008301 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW (May 2000). "PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation". Cell. 101 (2): 187–98. doi: 10.1016/S0092-8674(00)80829-6 . PMID 10786834. S2CID 8938256.
↑ "Entrez Gene: RNUXA RNA U, small nuclear RNA export adaptor (phosphorylation regulated)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Segref A, Mattaj IW, Ohno M (2001). "The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export". RNA. 7 (3): 351–60. doi:10.1017/S1355838201002278. PMC 1370092 . PMID 11333016.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Boulon S, Verheggen C, Jady BE, et al. (2005). "PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli". Mol. Cell. 16 (5): 777–87. doi: 10.1016/j.molcel.2004.11.013 . PMID 15574332.
Watkins NJ, Lemm I, Ingelfinger D, et al. (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl: 11858/00-001M-0000-0012-EB89-8 . PMID 15574333.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164902 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008301 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10786834-5] Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW (May 2000). "PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation". Cell. 101 (2): 187–98. doi: 10.1016/S0092-8674(00)80829-6 . PMID 10786834. S2CID 8938256.

[entrez-6] "Entrez Gene: RNUXA RNA U, small nuclear RNA export adaptor (phosphorylation regulated)".

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PHAX

Related Research Articles

References

Further reading