PHC3

PHC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PZN, 4PZO
Identifiers
Aliases	PHC3 , EDR3, HPH3, polyhomeotic homolog 3
External IDs	MGI: 2181434 HomoloGene: 69390 GeneCards: PHC3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	170,181,749 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	31,023,564 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; tibia; ; germinal epithelium; ; Achilles tendon; ; visceral pleura; ; parietal pleura; ; superficial temporal artery; ; urethra; ; seminal vesicula; ; Brodmann area 23;
	Top expressed in
	otolith organ; ; utricle; ; ciliary body; ; prostate; ; iris; ; aortic valve; ; retinal pigment epithelium; ; ascending aorta; ; lacrimal gland; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; zinc ion binding ; protein binding ; metal ion binding ;
Cellular component	PcG protein complex ; PRC1 complex ; nucleus ; nucleoplasm ;
Biological process	multicellular organism development ; negative regulation of G0 to G1 transition ;
	Sources:Amigo / QuickGO
Orthologs
	80012
	241915
	ENSG00000173889
	ENSMUSG00000037652
	Q8NDX5
	Q8CHP6
	NM_001308116 ; NM_024947
	NM_001165954 ; NM_001165955 ; NM_001165956 ; NM_153421
	NP_001295045 ; NP_079223
	NP_001159426 ; NP_001159427 ; NP_001159428 ; NP_700470
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Polyhomeotic-like protein 3 is a protein that in humans is encoded by the PHC3 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173889 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037652 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Aug 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol Cell Biol. 22 (17): 6070–6078. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016 . PMID 12167701.
↑ Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Hum Genet. 111 (4–5): 435–442. doi:10.1007/s00439-002-0814-3. PMID 12384788. S2CID 22192470.
↑ "Entrez Gene: PHC3 polyhomeotic homolog 3 (Drosophila)".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Deshpande AM, Akunowicz JD, Reveles XT, et al. (2007). "PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors". Oncogene. 26 (12): 1714–1722. doi:10.1038/sj.onc.1209988. PMC 2691996 . PMID 17001316.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173889 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037652 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12167701-5] Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Aug 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol Cell Biol. 22 (17): 6070–6078. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016 . PMID 12167701.

[pmid12384788-6] Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Hum Genet. 111 (4–5): 435–442. doi:10.1007/s00439-002-0814-3. PMID 12384788. S2CID 22192470.

[entrez-7] "Entrez Gene: PHC3 polyhomeotic homolog 3 (Drosophila)".

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PHC3

Related Research Articles

References

Further reading