PHF12

PHF12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L9S, 2LKM
Identifiers
Aliases	PHF12 , PF1, PHD finger protein 12
External IDs	MGI: 1924057 HomoloGene: 10841 GeneCards: PHF12
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 28,905,250 bp [1] End 28,951,771 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 77,873,580 bp [2] End 77,921,365 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve bone marrow cells stromal cell of endometrium spleen right lung blood appendix gastric mucosa ganglionic eminence right lobe of thyroid gland Top expressed in superior frontal gyrus thymus secondary oocyte lip yolk sac cerebellar cortex ganglionic eminence aortic valve lymph node ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor binding histone binding transcription corepressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein binding phosphatidylinositol binding metal ion binding Cellular component transcription repressor complex Sin3 complex nucleus nucleoplasm Sin3-type complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57649 268448 Ensembl ENSG00000109118 ENSMUSG00000037791 UniProt Q96QT6 Q5SPL2 RefSeq (mRNA) NM_001033561 NM_001290131 NM_020889 NM_174852 RefSeq (protein) NP_001028733 NP_001277060 NP_065940 NP_777277 Location (UCSC) Chr 17: 28.91 – 28.95 Mb Chr 11: 77.87 – 77.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene. ^{[5] [6]}

Interactions

PHF12 has been shown to interact with SIN3A. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000109118 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037791 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology. 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC   87072 . PMID   11390640.
6. "Entrez Gene: PHF12 PHD finger protein 12".

Further reading

• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Yochum GS, Ayer DE (November 2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC   134742 . PMID   12391155.
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331. S2CID   43194324.