PHLDA1

PHLDA1
Identifiers
Aliases	PHLDA1 , DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1
External IDs	OMIM: 605335; MGI: 1096880; HomoloGene: 7203; GeneCards: PHLDA1; OMA:PHLDA1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q21.2 Start 76,025,447 bp [1] End 76,031,776 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D1 Start 111,342,147 bp [2] End 111,344,506 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone stromal cell of endometrium ganglionic eminence salivary gland minor salivary glands gallbladder vagina right lung tibial nerve upper lobe of left lung Top expressed in parotid gland submandibular gland lacrimal gland left lobe of liver otic placode lactiferous gland crypt of lieberkuhn of small intestine epithelium of stomach granulocyte stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm cytoplasmic vesicle cytosol nucleus nucleolus Biological process apoptotic process FasL biosynthetic process G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22822 21664 Ensembl ENSG00000139289 ENSMUSG00000020205 UniProt Q8WV24 Q62392 RefSeq (mRNA) NM_007350 NM_009344 RefSeq (protein) NP_031376 NP_033370 Location (UCSC) Chr 12: 76.03 – 76.03 Mb Chr 10: 111.34 – 111.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene. ^{[5] [6] [7]}

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. ^[7]

Interactions

PHLDA1 has been shown to interact with RPL14, ^[8] EIF3D ^[8] and PABPC4. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000139289 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020205 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res. 62 (20): 5920–9. PMID   12384558.
6. Toyoshima Y; Karas M; Yakar S; Dupont J; Lee Helman; LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem. 279 (24): 25898–904. doi: 10.1074/jbc.M400661200 . PMID   15037619.
7. "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1".
8. Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5). England: 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN   0898-6568. PMID   11369516.

Further reading

• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID   9417904.
• Kuske MD, Johnson JP (2000). "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping". Cytogenet. Cell Genet. 89 (1–2): 1. doi:10.1159/000015575. PMID   10894922. S2CID   84103198.
• Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID   11369516.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hossain GS, van Thienen JV, Werstuck GH, et al. (2003). "TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia". J. Biol. Chem. 278 (32): 30317–27. doi: 10.1074/jbc.M212897200 . PMID   12738777.
• Oberg HH, Sipos B, Kalthoff H, et al. (2005). "Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells". Cell Death Differ. 11 (6): 674–84. doi: 10.1038/sj.cdd.4401407 . PMID   15002043.
• Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004). "A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation". Gene. 338 (2): 197–207. doi:10.1016/j.gene.2004.05.006. PMID   15315823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.