PHLDB1

PHLDB1
Identifiers
Aliases	PHLDB1 , LL5A, pleckstrin homology like domain family B member 1
External IDs	OMIM: 612834 MGI: 2143230 HomoloGene: 15903 GeneCards: PHLDB1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,658,031 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,735,198 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle frontal gyrus; ; gastric mucosa; ; left uterine tube; ; canal of the cervix; ; corpus callosum; ; subcutaneous adipose tissue; ; stromal cell of endometrium; ; right lung; ; right coronary artery;
	Top expressed in
	saccule; ; ankle joint; ; motor neuron; ; otic placode; ; molar; ; external carotid artery; ; calvaria; ; lip; ; white adipose tissue; ; internal carotid artery;
	More reference expression data
	More reference expression data
Orthologs
	23187
	102693
	ENSG00000019144
	ENSMUSG00000048537
	Q86UU1
	Q6PDH0
	NM_001144758 ; NM_001144759 ; NM_015157
	NM_153537
	NP_001138230 ; NP_001138231 ; NP_055972 ; NP_001138231.1
	NP_705765
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.^[5]^[6]

The first PHLDB1 cDNA was cloned from a rat pituitary cDNA library and named as LL5 after the clone number.^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000019144 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048537 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh M, Katoh M (Oct 2003). "Identification and characterization of human LL5A gene and mouse Ll5a gene in silico". Int J Oncol. 23 (5): 1477–83. doi:10.3892/ijo.23.5.1477. PMID 14532993.
↑ "Entrez Gene: PHLDB1 pleckstrin homology-like domain, family B, member 1".
↑ Levi L, Hanukoglu I, Raikhinstein M, Kohen F, Koch Y (16 November 1993). "Cloning of LL5, a novel protein encoding cDNA from a rat pituitary library". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (2): 342–4. doi:10.1016/0167-4781(93)90171-9. PMID 8241284.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.
Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362 . PMID 11001876.
Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951 . PMID 20513769.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000019144 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048537 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14532993-5] Katoh M, Katoh M (Oct 2003). "Identification and characterization of human LL5A gene and mouse Ll5a gene in silico". Int J Oncol. 23 (5): 1477–83. doi:10.3892/ijo.23.5.1477. PMID 14532993.

[entrez-6] "Entrez Gene: PHLDB1 pleckstrin homology-like domain, family B, member 1".

[7] Levi L, Hanukoglu I, Raikhinstein M, Kohen F, Koch Y (16 November 1993). "Cloning of LL5, a novel protein encoding cDNA from a rat pituitary library". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (2): 342–4. doi:10.1016/0167-4781(93)90171-9. PMID 8241284.

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PHLDB1

Related Research Articles

References

Further reading