PHLDB2

PHLDB2
Identifiers
Aliases	PHLDB2 , LL5b, LL5beta, pleckstrin homology like domain family B member 2
External IDs	OMIM: 610298; MGI: 2444981; HomoloGene: 17100; GeneCards: PHLDB2; OMA:PHLDB2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.2 Start 111,732,497 bp [1] End 111,976,517 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B5 Start 45,566,606 bp [2] End 45,773,961 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle tail of epididymis parietal pleura placenta Achilles tendon decidua right ventricle cardiac muscle tissue of right atrium tibial arteries visceral pleura Top expressed in genital tubercle renal corpuscle left lung lobe urothelium gastrula medullary collecting duct tunica media of zone of aorta transitional epithelium of urinary bladder calvaria Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding cadherin binding Cellular component plasma membrane intermediate filament cytoskeleton basal cortex cell leading edge membrane focal adhesion cytoplasm cytosol Biological process negative regulation of wound healing, spreading of epidermal cells regulation of epithelial to mesenchymal transition regulation of microtubule cytoskeleton organization positive regulation of basement membrane assembly involved in embryonic body morphogenesis negative regulation of stress fiber assembly regulation of gastrulation microtubule cytoskeleton organization negative regulation of focal adhesion assembly establishment of protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90102 208177 Ensembl ENSG00000144824 ENSMUSG00000033149 UniProt Q86SQ0 Q8K1N2 RefSeq (mRNA) NM_145753 NM_001134437 NM_001134438 NM_001134439 NM_001252442 NM_153412 NM_001357078 RefSeq (protein) NP_001127909 NP_001127910 NP_001127911 NP_665696 NP_001239371 NP_700461 NP_001344007 Location (UCSC) Chr 3: 111.73 – 111.98 Mb Chr 16: 45.57 – 45.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene. ^{[5] [6]}

Interactions

PHLDB2 has been shown to interact with FLNC. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144824 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033149 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem. 278 (2): 1328–35. doi: 10.1074/jbc.M208352200 . PMID   12376540.
6. "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".

Further reading

• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC   1221362 . PMID   11001876.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi: 10.1016/j.devcel.2006.05.012 . PMID   16824950.
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC   2878951 . PMID   20513769.